GRANT Friday, November 28, 2014- 14:00 Alzheimer's Research UK £500,000 23 January 2015 Global Clinical Trials Fund ...
Martin Citron on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT Over the last years a number of studies have addressed potential on-target liabilities of therapeutic BACE1 inhibition. Many of these studies were based on knockout data alone, or addressed developmental myelination. In contrast, the new study by Herms ...
Stefan Lichtenthaler on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT This is an interesting paper, which fits well with earlier findings reported from Phil Wong’s lab in BACE1-deficient mice (Savonenko et al., 2008). After Carmen Birchmeier’s report last year (Cheret et al., 2013), this is now another story demonstrating ...
RESEARCH NEWS 2014-11-28 Research News The goal of BACE1 inhibition is to stop the production of toxic Aβ. However, a new study reports that at very high doses, the inhibitors may harm the very neurons they are meant to protect. Initial findings were presented by senior author ...
PAPER Farhad SZ, Amini S, Khalilian A, Barekatain M, Mafi M, Barekatain M, Rafei E
The effect of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease.Dent Res J (Isfahan). 2014 Sep;11(5):549-552. PubMed: 25426144
PAPER Darusman HS, Gjedde A, Sajuthi D, Schapiro SJ, Kalliokoski O, Kristianingrum YP, Handaryani E, Hau J
Amyloid Beta1-42 and the Phoshorylated Tau Threonine 231 in Brains of Aged Cynomolgus Monkeys (Macaca fascicularis).Front Aging Neurosci. 2014;6:313. Epub 2014 Nov 10 PubMed: 25426069
PAPER Wilkins HM, Carl SM, Greenlief AC, Festoff BW, Swerdlow RH25426068
PAPER Yuan TF, Shan C25424433
PAPER Fujishima M, Maikusa N, Nakamura K, Nakatsuka M, Matsuda H, Meguro K
Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities.Front Aging Neurosci. 2014;6:306. Epub 2014 Nov 7 PubMed: 25426066
PAPER Mandas A, Mereu RM, Catte O, Saba A, Serchisu L, Costaggiu D, Peiretti E, Caminiti G, Vinci M, Casu M, Piludu S, Fossarello M, Manconi PE, Dessí S
Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population.Front Aging Neurosci. 2014;6:309. Epub 2014 Nov 7 PubMed: 25426067
PAPER Schaffer C, Sarad N, DeCrumpe A, Goswami D, Herrmann S, Morales J, Patel P, Osborne J25424384
PAPER McCarthy P, Benuskova L, Franz EA
The age-related posterior-anterior shift as revealed by voxelwise analysis of functional brain networks.Front Aging Neurosci. 2014;6:301. Epub 2014 Nov 7 PubMed: 25426065
PAPER Orsini F, De Blasio D, Zangari R, Zanier ER, De Simoni MG25426028
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