PAPER Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP

Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.

Free Radic Biol Med. 2012 Apr 15;52(8):1294-306. PubMed: 22334051

PAPER Lugert S, Vogt M, Tchorz JS, Müller M, Giachino C, Taylor V

Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1(high) intermediate progenitors.

Nat Commun. 2012;3:670. PubMed: 22334073

PAPER Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Nat Neurosci. 2012 Jan;15(1):70-80. PubMed: 22158513

PAPER Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S

Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide.

Glia. 2012 May;60(5):761-70. PubMed: 22331560

PAPER Walterfang M, Macfarlane MD, Looi JC, Abel L, Bowman E, Fahey MC, Desmond P, Velakoulis D

Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann-Pick disease type C.

Eur J Neurol. 2012 Mar;19(3):462-7. PubMed: 22329857

Maria Björkqvist

Lund University
Sweden

Thomas Pochapsky on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

COMMENT We shouldn’t lose sight of the most important aspect of this controversy, which is that α-synuclein can, and does, take on different forms in response to the local environment, and likely occupies multiple states in vivo. In other words, it is a moving ta

Michael K. Lee on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

COMMENT The report from the collaborative Lashuel group is a careful but partial rebuttal of two recent reports (Bartels et al., 2011 and Wang et al., 2011) that concluded that α-synuclein in cells exists as a stable tetramer. In the current report, Fauvet et al.

Thomas Pochapsky

Brandeis University
Waltham, United States

Michael Ewers on Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals.

COMMENT The study by Perrotin et al. shows that subtle decreases in memory and an accompanying awareness of reduced memory performance is associated with higher PIB-PET imaging of β amyloid (Aβ) in the brains of asymptomatic, cognitively normal elders. In view of

Michael Ewers

University of California, San Francisco
San Francisco, United States

Pat McGeer on Upping Brain ApoE, Drug Treats Alzheimer's Mice

COMMENT The report by Cramer et al. is potentially exciting because it offers a plausible explanation as to why ApoE4 should be a risk factor for AD, and more importantly suggests that bexarotene, an off-the-shelf retinoid X receptor agonist, may prove to be an e

Claudia Schwab

University of Bristish Columbia
Vancouver, Canada

Jian-Ping Guo

Canada

PAPER Boehm M, Slack F

A developmental timing microRNA and its target regulate life span in C. elegans.

Science. 2005 Dec 23;310(5756):1954-7. PubMed: 16373574