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Chi Tarn on Immunogenicity of induced pluripotent stem cells.

COMMENT This paper by Zhao et al. demonstrates that allogeneic embryonic stem cell (ESC) transplantation is more immunogenic than syngeneic ESC transplantation in mice. Likewise, allogeneic induced pluripotent stem cell (iPSC) transplantation is less immunogenic

Chi Tarn


Coriell Institute for Medical Research
Camden, United States

Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus

WEBINAR 2011-06-01 Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for Resear

PAPER Hutson PH, Finger EN, Magliaro BC, Smith SM, Converso A, Sanderson PE, Mullins D, Hyde LA, Eschle BK, Turnbull Z, Sloan H, Guzzi M, Zhang X, Wang A, Rindgen D, Mazzola R, Vivian JA, Eddins D, Uslaner JM, Bednar R, Gambone C, Le-Mair W, Marino MJ, Sachs N, Xu G, Parmentier-Batteur S

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in

Neuropharmacology. 2011 Sep;61(4):665-76. PubMed: 21619887

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