PAPER Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

Neuron. 2012 May 24;74(4):691-705. PubMed: 22632727

Henrietta Nielsen on Is α-Synuclein the Third Musketeer in AD Pathophysiology?

COMMENT Several recent studies have reported significantly decreased levels of cerebrospinal fluid (CSF) α-synuclein levels specifically in patients with synucleinopathies including Parkinson's disease (PD), multiple systems atrophy (MSA), and dementia with

Gianluigi Forloni on Tracing Aβ’s Toxicity Through Prion Protein, Fyn Kinase

COMMENT This paper by the Strittmatter group describes a significant number of data; however, the relevance of these results remains unclear. All the in-vitro data are produced with short exposure to oligomers (15-20 minutes, sometimes hours). We do not know how

Paul Axelsen

University of Pennsylvania
United States

Josef Hlasny

Czech Republic

Jessica Gabin

HUNT Research Centre
Norway

CSF Markers: Goodbye, Research Use Only; Hello, Clinical

CONFERENCE COVERAGE 2012-08-01 Conference Coverage What a difference a year can make. At the 2011 Alzheimer’s Association International Conference in Paris, France, leading scientists in the CSF Alzheimer’s biomarker field met to tackle the vexing problem of measurement variability wit

Is α-Synuclein the Third Musketeer in AD Pathophysiology?

RESEARCH NEWS 2012-08-01 Research News Alzheimer’s disease is usually thought of as a disorder of two proteins, Aβ and tau, but α-synuclein may be equally important to the disease process, according to a July 25 Journal of Neuroscience paper. Researchers led by Sylvain Lesné at t

Presidential Early Career Award for Neuroscientist

COMMUNITY NEWS 2012-08-01 Community News Beth Stevens, Children’s Hospital, Boston, was one of 96 scientists and engineers who received Presidential Early Career Award for Scientists and Engineers at a ceremony in the East Room of the White House on Tuesday, 31 July 2012. The awar

PAPER Hardiman O, Figlewicz DA

The expansions of ALS.

Neurology. 2012 Jul 25; PubMed: 22843260

PAPER Peacey E, Rodriguez L, Liu Y, Wolfe MS

Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing.

Nucleic Acids Res. 2012 Oct 1;40(19):9836-49. PubMed: 22844088

PAPER Arduíno DM, Raquel Esteves A, Cortes L, Silva DF, Patel B, Grazina M, Swerdlow RH, Oliveira CR, Cardoso SM

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic.

Hum Mol Genet. 2012 Nov 1;21(21):4680-702. PubMed: 22843496

PAPER Bidinosti M, Shimshek DR, Mollenhauer B, Marcellin D, Schweizer T, Lotz GP, Schlossmacher MG, Weiss A

Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING.

J Biol Chem. 2012 Sep 28;287(40):33691-705. PubMed: 22843695

PAPER Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Knopman DS, Kretzschmar HA, Neumann M, Caselli RJ, White CL, Mackenzie IR, Petersen RC, Strong MJ, Miller BL, Boeve BF, Uitti RJ, Boylan KB, Wszolek ZK, Graff-Radford NR, Dickson DW, Ross OA, Rademakers R

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype.

Neurobiol Aging. 2012 Dec;33(12):2950.e5-7. PubMed: 22840558

PAPER Hamlin C, Puoti G, Berri S, Sting E, Harris C, Cohen M, Spear C, Bizzi A, Debanne SM, Rowland DY

A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.

Neurology. 2012 Aug 7;79(6):547-52. PubMed: 22843257