PAPER Forlenza OV, Diniz BS, Teixeira AL, Stella F, Gattaz W
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329930 RESULTS
PAPER Ahmed S, Haigh AM, de Jager CA, Garrard P
Connected speech as a marker of disease progression in autopsy-proven Alzheimer's disease.
Brain. 2013 Oct 18; PubMed: 24142144PAPER Roussotte FF, Daianu M, Jahanshad N, Leonardo CD, Thompson PM
Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.
Brain Imaging Behav. 2013 Oct 20; PubMed: 24142306PAPER Harris JM, Gall C, Thompson JC, Richardson AM, Neary D, Du Plessis D, Pal P, Mann DM, Snowden JS, Jones M
Classification and pathology of primary progressive aphasia.
Neurology. 2013 Nov 19;81(21):1832-9. PubMed: 24142474PAPER Du LL, Xie JZ, Cheng XS, Li XH, Kong FL, Jiang X, Ma ZW, Wang JZ, Chen C, Zhou XW
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Age (Dordr). 2013 Oct 20; PubMed: 24142524PAPER Todd PK, Paulson HL
C9orf72-Associated FTD/ALS: When Less Is More.
Neuron. 2013 Oct 16;80(2):257-8. PubMed: 24139028PAPER Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention.
Neuron. 2013 Oct 16;80(2):415-28. PubMed: 24139042Carlos Cruchaga on Fall Flurry of Letters Kicks Up Dust Around TREM2
COMMENT In the recent correspondence to the NEJM about the initial TREM2 findings, Bruno Benitez and I reported an association between the TREM2 R47H variant and Parkinson's disease risk. However it looks like neither Dr. Guerreiro nor Dr. Jonsson found the
Larry Baum on Sleep Patterns, Circadian Clock Linked to Aβ Oxidative Stress
COMMENT In the October 18 Science, Xie et al. report that cerebrospinal fluid flow through the interstitial space of the brain increases during sleep. This increased flow might function to clear undesirable metabolites from the brain. If humans are also shown to
Tara Spires-Jones on Antibodies Stop Toxic Tau in Its Extracellular Tracks
COMMENT This is a very interesting paper contributing to the growing body of evidence that passive immunotherapy may be able to prevent the spread of pathological forms of tau. There have been several promising studies on this concept, but in this paper, Yanamand
PAPER Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M
Sleep drives metabolite clearance from the adult brain.
Science. 2013 Oct 18;342(6156):373-7. PubMed: 24136970Michael Vitek on Shutdown Grabs Headlines, but Sequestration Does Real Damage
COMMENT The U.S. Alzheimer's community is an outstanding contributor to the worldwide effort to slow, halt, and reverse AD. While Congress's attitude toward science and the sequestration reductions does not help, there are several immediate, temporary,
PSEN1 L381F
MUTATIONS PSEN1 73683845 GRCh37/hg19 C T Exon 11 Point, Missense Coding In silico analysis suggests that the mutation affects the folding free energy and flexibility of the protein. Neuropathology consistent with AD, including neuritic amyoid plaques and neurofibri
MAPT N410H
MUTATIONS MAPT 44101439 GRCh37/hg19 A C Exon 13 Point, Missense Coding Increase in the 4R/3R tau-mRNA ratio in patient brain. Recombinant tau with the N410H mutation had increased tau filament formation compared with wild-type tau, a decreased rate of microtubule a
PAPER Morihara T, Kudo T, Ikura Y, Kashiwagi Y, Miyamae Y, Nakamura Y, Tanaka T, Shinozaki K, Nishikawa T, Takeda M
Increased tau protein level in postmortem cerebrospinal fluid.
Psychiatry Clin Neurosci. 1998 Feb;52(1):107-10. PubMed: 9682942Current Filters
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