PAPER Mausbach BT, Chattillion EA, Roepke SK, Patterson TL, Grant I
SEARCH RESULTS
329967 RESULTS
PAPER Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
Cell Rep. 2013 Jan 31;3(1):42-51. PubMed: 23291095PAPER Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, LaDu MJ
Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
J Biol Chem. 2013 Feb 22;288(8):5914-26. PubMed: 23293020Adam Green on Does ApoE4 Risk Begin in the Womb?
COMMENT This is a very interesting study looking at an incredible dataset of MRI scans from 272 infants. The size of the study is one of its great strengths, so when the researchers are analyzing ApoE genotype, they have enough individuals to make interesting com
William Jagust on Does ApoE4 Risk Begin in the Womb?
COMMENT I think this is consistent with a theme that is gradually emerging in the literature: ApoE has effects on the brain that are not simply related to its effect on the processing of Aβ. One always has to be concerned about the issue of multiple comparisons w
Adam Green
Georgetown UniversityWashington, United States
PAPER Kirby J, Highley JR, Cox L, Goodall EF, Hewitt C, Hartley JA, Hollinger HC, Fox M, Ince PG, McDermott CJ, Shaw PJ
Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.
Neuropathol Appl Neurobiol. 2012 Dec 10; PubMed: 23228179PAPER Lattante S, Conte A, Zollino M, Luigetti M, Del Grande A, Marangi G, Romano A, Marcaccio A, Meleo E, Bisogni G, Rossini PM, Sabatelli M
Contribution of major amyotrophic lateral sclerosis genes to the etiology of sporadic disease.
Neurology. 2012 Jul 3;79(1):66-72. PubMed: 22722621PAPER Giannini F, Battistini S, Mancuso M, Greco G, Ricci C, Volpi N, Del Corona A, Piazza S, Siciliano G
D90A-SOD1 mutation in ALS: The first report of heterozygous Italian patients and unusual findings.
Amyotroph Lateral Scler. 2010;11(1-2):216-9. PubMed: 20184519PAPER Kühnlein P, Sperfeld AD, Vanmassenhove B, Van Deerlin V, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph AC, Neumann M
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations.
Arch Neurol. 2008 Sep;65(9):1185-9. PubMed: 18779421PAPER van Blitterswijk M, van Es MA, Koppers M, van Rheenen W, Medic J, Schelhaas HJ, van der Kooi AJ, de Visser M, Veldink JH, van den Berg LH
VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient.
Neurobiol Aging. 2012 Dec;33(12):2950.e1-4. PubMed: 22878164PAPER van Blitterswijk M, van Es MA, Hennekam EA, Dooijes D, van Rheenen W, Medic J, Bourque PR, Schelhaas HJ, van der Kooi AJ, de Visser M, de Bakker PI, Veldink JH, van den Berg LH
Evidence for an oligogenic basis of amyotrophic lateral sclerosis.
Hum Mol Genet. 2012 Sep 1;21(17):3776-84. Epub 2012 May 29 PubMed: 22645277PAPER Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, Palazuelos E, Weiss ST, Hernandez-Avila M
Apolipoprotein E genotype predicts 24-month bayley scales infant development score.
Pediatr Res. 2003 Dec;54(6):819-25. PubMed: 12930912Tomas Odergren
Karolinska DevelopmentSweden
Juanita Ippel
Alzheimer Research CenterAmsterdam, Netherlands
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