PAPER Thored P, Arvidsson A, Cacci E, Ahlenius H, Kallur T, Darsalia V, Ekdahl CT, Kokaia Z, Lindvall O

Persistent production of neurons from adult brain stem cells during recovery after stroke.

Stem Cells. 2006 Mar;24(3):739-47. PubMed: 16210404

PAPER Li L, Harms KM, Ventura PB, Lagace DC, Eisch AJ, Cunningham LA

Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic.

Glia. 2010 Oct;58(13):1610-9. PubMed: 20578055

PAPER Benner EJ, Luciano D, Jo R, Abdi K, Paez-Gonzalez P, Sheng H, Warner DS, Liu C, Eroglu C, Kuo CT

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.

Nature. 2013 Apr 24; PubMed: 23615612

PAPER Perry EK, Curtis M, Dick DJ, Candy JM, Atack JR, Bloxham CA, Blessed G, Fairbairn A, Tomlinson BE, Perry RH

Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

J Neurol Neurosurg Psychiatry. 1985 May;48(5):413-21. PubMed: 3998751

PAPER Strong R, Hicks P, Hsu L, Bartus RT, Enna SJ

Age-related alterations in the rodent brain cholinergic system and behavior.

Neurobiol Aging. 1980 Summer;1(1):59-63. PubMed: 7266736

PAPER Cassel JC, Gaurivaud M, Lazarus C, Bertrand F, Galani R, Jeltsch H

Grafts of fetal septal cells after cholinergic immunotoxic denervation of the hippocampus: a functional dissociation between dorsal and ventral implantation sites.

Neuroscience. 2002;113(4):871-82. PubMed: 12182893

PAPER Leanza G, Martìnez-Serrano A, Björklund A

Amelioration of spatial navigation and short-term memory deficits by grafts of foetal basal forebrain tissue placed into the hippocampus and cortex of rats with selective cholinergic lesions.

Eur J Neurosci. 1998 Jul;10(7):2353-70. PubMed: 9749764

PAPER Gage FH, Björklund A, Stenevi U, Dunnett SB, Kelly PA

Intrahippocampal septal grafts ameliorate learning impairments in aged rats.

Science. 1984 Aug 3;225(4661):533-6. PubMed: 6539949

Brian Popko on Oligodendrocyte Support System Fails Early in ALS

COMMENT This is a very well-done study that provides strong evidence that oligodendrocytes, the cells responsible for myelinating the central nervous system, contribute to disease pathogenesis in ALS. This is particularly exciting because it demonstrates a critic

Brian Popko

University of Chicago
United States

Cynthia Lemere on Aβ Vaccine Leads to Safer Immune Response in Mice

COMMENT The article by Browne et al. under "Related Papers" (Browne et al., 2013) directly addresses why it may be beneficial not only reduce to amyloid-β with targeted antibodies, but also to promote an anti-inflammatory Th2 and T regulatory response t

Takaomi Saido on Brain amyloid-β oligomers in ageing and Alzheimer's disease.

COMMENT The group led by Karen Ashe presents an important finding that Aβ*56, not dimers or trimers, correlate with "pathological tau" proteins and postsynaptic proteins in human brains. Everyone in the AD research field should read this paper carefully

Takaomi Saido on Fluorine-18 radiolabeled heterocycles as PET tracers for imaging β-amyloid plaques in Alzheimer's disease.

COMMENT This is a nice update of [18F]-labeled PET ligands for amyloid imaging. 0 saido

Takaomi Saido on A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.

COMMENT This work deserves a lot of attention. One thing that is unclear is the definition of tauopathy. 0 saido

Peter Blackburn

Mercia Pharma, Inc.
New York, United States