PAPER Toledo JB, Da X, Bhatt P, Wolk DA, Arnold SE, Shaw LM, Trojanowski JQ, Davatzikos C,

Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI.

PLoS One. 2013;8(2):e55531. PubMed: 23408997

PAPER Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T

Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice.

PLoS One. 2013;8(2):e55774. PubMed: 23409038

PAPER Sandebring A, Welander H, Winblad B, Graff C, Tjernberg LO

The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.

PLoS One. 2013;8(2):e55847. Epub 2013 Feb 11 PubMed: 23409063

Edwin J. Weeber on Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?

COMMENT The elegant study by Rasgon and colleagues identifies yet another unknown consequence of ApoE4 expression: increased telomere (TL) shortening. Furthermore, this study suggests that hormone replacement therapy (HT) can effectively counteract these changes

PAPER Sayed Y, Taxel P

The use of estrogen therapy in men.

Curr Opin Pharmacol. 2003 Dec;3(6):650-4. PubMed: 14644018

Mark Mattson on Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?

COMMENT There has been a flurry of articles published within the past few years in which relatively shorter telomere length in lymphocytes has been associated with aging and numerous chronic diseases. A common factor in these conditions is that there is elevated

Boris Rogelj on Second Study Sees Intron in FTLD Gene Translated

COMMENT In less than a week, two publications reveal the existence of a relatively obscure process of translation—repeat-associated non-ATG (RAN) translation in C9ORF72-associated ALS and FTD. RAN translation has already been shown in two other repeat-associated

Ole Isacson on Brain Electrodes Help Early PD, But Still Risky and Costly

COMMENT I think the trial is too short (two years) to address the most important caveat: the loss of DBS efficacy over time. Hence, the trial is not well conceived, in my opinion. Another issue is that the actual rationale for DBS use—as the authors themselves st

PAPER Tanner CM

A second honeymoon for Parkinson's disease?

N Engl J Med. 2013 Feb 14;368(7):675-6. PubMed: 23406033

PAPER Boccard SG, Pereira EA, Moir L, Aziz TZ, Green AL

Long-term Outcomes of Deep Brain Stimulation for Neuropathic Pain.

Neurosurgery. 2013 Feb;72(2):221-31. PubMed: 23149975

PAPER Moro E, Lozano AM, Pollak P, Agid Y, Rehncrona S, Volkmann J, Kulisevsky J, Obeso JA, Albanese A, Hariz MI, Quinn NP, Speelman JD, Benabid AL, Fraix V, Mendes A, Welter ML, Houeto JL, Cornu P, Dormont D, Tornqvist AL, Ekberg R, Schnitzler A, Timmermann L, Wojtecki L, Gironell A, Rodriguez-Oroz MC, Guridi J, Bentivoglio AR, Contarino MF, Romito L, Scerrati M, Janssens M, Lang AE

Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease.

Mov Disord. 2010 Apr 15;25(5):578-86. PubMed: 20213817

PAPER Fasano A, Romito LM, Daniele A, Piano C, Zinno M, Bentivoglio AR, Albanese A

Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants.

Brain. 2010 Sep;133(9):2664-76. PubMed: 20802207

PAPER Schüpbach WM, Maltête D, Houeto JL, du Montcel ST, Mallet L, Welter ML, Gargiulo M, Béhar C, Bonnet AM, Czernecki V, Pidoux B, Navarro S, Dormont D, Cornu P, Agid Y

Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.

Neurology. 2007 Jan 23;68(4):267-71. PubMed: 17151341

Bo Qin

University of North Carolina at Chapel Hill School of Public Health
Chapel Hill, United States

PAPER Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Science. 2013 Mar 15;339(6125):1335-8. Epub 2013 Feb 7 PubMed: 23393093