Lotta Agholme

Cellectricon AB
Gothenburg, Sweden

CTAD: AD Treatment Might Not Lower Healthcare Costs

CONFERENCE COVERAGE 2012-11-21 Conference Coverage Stakeholders in the Alzheimer’s disease field often cite the tremendous burden the disease puts on the healthcare system—estimated at $600 billion annually worldwide (see World Alzheimer Report 2010 and ARF related news story)—as a com

Boxing: Study of Human Model for CTE Enters Second Round

CONFERENCE COVERAGE 2012-11-21 Conference Coverage Viewed through a scientist’s lens, professional boxing is a series of scheduled, measurable head traumas. In other words, it is a human model for chronic traumatic encephalopathy (CTE). Seen this way, the sport offers a unique opportun

Déjà Vu? AD Patients Again Look Worse on γ-Secretase Inhibitor

RESEARCH NEWS 2012-11-21 Research News In a Phase 2 trial of Bristol-Myers Squibb’s oral γ-secretase inhibitor avagacestat, AD patients who took high doses suffered more adverse effects and appeared to fare worse cognitively than those on placebo. Christopher van Dyck of Yale Uni

SfN: Epigenetic Changes in Alzheimer’s and Cognitive Decline

CONFERENCE COVERAGE 2012-11-21 Conference Coverage Franklin’s genius notwithstanding, death and taxes are not the only things that are certain. It’s pretty clear you can’t evade your genetics, either. But what about epigenetics? While tweaking the tax code might improve your fortune, c

PAPER Bertoux M, Volle E, Funkiewiez A, de Souza LC, Leclercq D, Dubois B

Social Cognition and Emotional Assessment (SEA) is a marker of medial and orbital frontal functions: a voxel-based morphometry study in behavioral variant of frontotemporal degeneration.

J Int Neuropsychol Soc. 2012 Nov;18(6):972-85. PubMed: 23158228

PAPER Barandiaran M, Estanga A, Moreno F, Indakoetxea B, Alzualde A, Balluerka N, Martí Massó JF, de Munain AL

Neuropsychological features of asymptomatic c.709-1G> A progranulin mutation carriers.

J Int Neuropsychol Soc. 2012 Nov;18(6):1086-90. PubMed: 23158232

PAPER van Blitterswijk M, Dejesus-Hernandez M, Rademakers R

How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders?

Curr Opin Neurol. 2012 Dec;25(6):689-700. PubMed: 23160421

PAPER Goodwin J, Nath S, Engelborghs Y, Pountney DL

Raised calcium and oxidative stress cooperatively promote alpha-synuclein aggregate formation.

Neurochem Int. 2012 Nov 15; PubMed: 23159813

PAPER Narayanan C, Weinstock DS, Wu KP, Baum J, Levy RM

Investigation of the Polymeric Properties of α-Synuclein and Comparison with NMR Experiments: A Replica Exchange Molecular Dynamics Study.

J Chem Theory Comput. 2012 Oct 9;8(10):3929-3942. PubMed: 23162382

PAPER Thakur P, Nehru B

Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease.

Neuroscience. 2013 Feb 12;231:420-31. PubMed: 23159314

PAPER Liu J, Shen Y, Li M, Shi Q, Zhang A, Miao F, Wu X, He Y, Zhang J

The expression pattern of classical MHC class I molecules in the development of mouse central nervous system.

Neurochem Res. 2013 Feb;38(2):290-9. PubMed: 23161087

PAPER Chamberland S, Topolnik L

Inhibitory control of hippocampal inhibitory neurons.

Front Neurosci. 2012;6:165. PubMed: 23162426

PAPER Zhang G, Morin C, Zhu X, Bao Huynh M, Ouidir Ouidja M, Sepulveda-Diaz JE, Raisman-Vozari R, Li P, Papy-Garcia D

Self-evolving oxidative stress with identifiable pre- and postmitochondrial phases in PC12 cells.

J Neurosci Res. 2013 Feb;91(2):273-84. PubMed: 23161662

PAPER Wisniewska MB, Nagalski A, Dabrowski M, Misztal K, Kuznicki J

Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability.

BMC Genomics. 2012;13:635. PubMed: 23157480