Pierre Lau Poui Cheung on TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
COMMENT The regulation of miRNA biogenesis by TAR DNA-binding protein 43 (TDP-43) represents a bridge between neurodegeneration and regulation of genes at the post-transcriptional level. TDP-43 is the major constituent of inclusions in amyotrophic lateral scleros