To Reveal or Not to Reveal? New Data on the Question

CONFERENCE COVERAGE 2012-08-13 Conference Coverage As the Alzheimer’s disease (AD) field moves closer to using genetic and biomarker data to identify people at risk, researchers are urgently trying to tackle whether and how to disclose that information to people in both routine clinica

Does AD in the Oldest Old Resemble Normal Aging?

RESEARCH NEWS 2012-08-13 Research News When does Alzheimer’s disease (AD) look like normal aging? In the oldest old, suggest scientists led by Dominic Holland, University of California, San Diego. Writing in the August 2 PLoS ONE, Holland and colleagues report that AD-associated

PAPER Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes.

PLoS One. 2012;7(8):e42545. PubMed: 22880029

PAPER Suzuki N, Kato S, Kato M, Warita H, Mizuno H, Shimakura N, Akiyama H, Kobayashi Z, Konno H, Aoki M

FUS/TLS-immunoreactive neuronal and glial cell inclusions increase with disease duration in familial amyotrophic lateral sclerosis with an R521C FUS/TLS mutation.

J Neuropathol Exp Neurol. 2012 Sep;71(9):779-88. PubMed: 22878663

PAPER Walker LC, Levine H

Corruption and spread of pathogenic proteins in neurodegenerative diseases.

J Biol Chem. 2012 Sep 28;287(40):33109-15. PubMed: 22879600

PAPER Parker SJ, Meyerowitz J, James JL, Liddell JR, Nonaka T, Hasegawa M, Kanninen KM, Lim S, Paterson BM, Donnelly PS, Crouch PJ, White AR

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

PLoS One. 2012;7(8):e42277. PubMed: 22879928

PAPER El Akabawy G, Rattray I, Johansson SM, Gale R, Bates G, Modo M

Implantation of undifferentiated and predifferentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.

BMC Neurosci. 2012 Aug 9;13(1):97. PubMed: 22876937

PAPER Halliday G, Bigio EH, Cairns NJ, Neumann M, Mackenzie IR, Mann DM

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects.

Acta Neuropathol. 2012 Sep;124(3):373-82. PubMed: 22878865

PAPER Shah I, Petroczi A, Tabet N, Klugman A, Isaac M, Naughton DP

Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls.

Curr Alzheimer Res. 2012 Aug 8; PubMed: 22876849

PAPER Catindig JA, Venketasubramanian N, Ikram MK, Chen C

Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors.

J Neurol Sci. 2012 Oct 15;321(1-2):11-6. PubMed: 22877510

PAPER Arlt S, Müller-Thomsen T, Beisiegel U, Kontush A

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer's Disease.

Neurochem Res. 2012 Aug 10; PubMed: 22878647

PAPER Lucas HR, Rifkind JM

Considering the vascular hypothesis of Alzheimer's disease: effect of copper associated amyloid on red blood cells.

Adv Exp Med Biol. 2013;765:131-8. PubMed: 22879025

PAPER Chang YT, Chang CC, Lin HS, Huang CW, Chang WN, Lui CC, Lee CC, Lin YT, Chen CH, Chen NC

Montreal cognitive assessment in assessing clinical severity and white matter hyperintensity in Alzheimer's disease with normal control comparison.

Acta Neurol Taiwan. 2012 Jun;21(2):64-73. PubMed: 22879115

PAPER Graewe B, Lemos R, Ferreira C, Santana I, Farivar R, De Weerd P, Castelo-Branco M

Impaired Processing of 3D Motion-Defined Faces in Mild Cognitive Impairment and Healthy Aging: An fMRI Study.

Cereb Cortex. 2012 Aug 9; PubMed: 22879351

PAPER Bien J, Jefferson T, Causevic M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species.

J Biol Chem. 2012 Sep 28;287(40):33304-13. PubMed: 22879596