MUTATIONS PSEN1 Exon 5 Point, Missense Coding Unknown. Unknown. I148W Parkinson's Disease Dementia: Unclear PathogenicityParkinson's Disease Dementia This mutation was identified in an individual with apparently sporadic Parkinson’s disease with dementia ...
MUTATIONS PSEN1 Exon 10 Point, Missense Coding Unknown. Unknown; imaging showed cerebral global atrophy. R352C Alzheimer's Disease: Unclear PathogenicityAlzheimer's Disease This mutation was reported in a Chinese Han family with a history of early-onset ...
Gerold Schmitt-Ulms on A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology
COMMENT This study by Matarin et al. is, by a considerable margin, the largest microarray-based investigation of Alzheimer’s disease (AD) mouse models to date. The authors monitored and compared transcript levels of more than 12,500 genes in five AD models (plus ...
RESEARCH NEWS 2015-01-25 Research News Amyloid plaques and tau tangles both characterize Alzheimer’s, but how does each drive the disease? A new study in the February 3 Cell Reports aims to disentangle their relative contributions to AD pathology. Researchers led by Frances ...
PAPER Paradowska-Gorycka A, Jurkowska M23459077
PAPER Matarin M, Salih DA, Yasvoina M, Cummings DM, Guelfi S, Liu W, Nahaboo Solim MA, Moens TG, Moreno Paublete R, Ali SS, Perona M, Desai R, Smith KJ, Latcham J, Fulleylove M, Richardson JC, Hardy J, Edwards FA
RESEARCH NEWS 2015-01-23 Research News One strategy scientists are trying to slow the progression of Alzheimer’s is inhibiting the BACE1 enzyme that cleaves the amyloid precursor protein (APP). However, since BACE1 cuts a range of other substrates, side effects are a concern. One ...
PAPER Isaji T, Kariya Y, Xu Q, Fukuda T, Taniguchi N, Gu J20816221
PAPER Zhao Y, Sato Y, Isaji T, Fukuda T, Matsumoto A, Miyoshi E, Gu J, Taniguchi N18384383
PAPER Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson JC, Marth JD, Varki N
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.Glycobiology. 2013 Mar;23(3):363-80. Epub 2012 Oct 31 PubMed: 23118208
PAPER Song Y, Aglipay JA, Bernstein JD, Goswami S, Stanley P
The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression.Cancer Res. 2010 Apr 15;70(8):3361-71. PubMed: 20395209
PAPER Nicoll RA, Kauer JA, Malenka RC2856092
PAPER Taniguchi N, Korekane H
Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics.BMB Rep. 2011 Dec;44(12):772-81. PubMed: 22189679
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