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Brian Downer
University of KentuckyWallis and Futuna
Jacobo E. Mintzer on Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging.
COMMENT This is really interesting and goes against the usual interpretation that increased blood glucose due to poor sugar control will lead to increases in AD. We have noticed a similar trend, showing that poor glucose control (high blood glucose) results in re
Lotta Granholm
Medical University of South CarolinaUnited States
David L. Bachman
Medical University of South CarolinaUnited States
Jacobo E. Mintzer
Medical University of South CarolinaUnited States
Michael Wolfe on The crystal structure of GXGD membrane protease FlaK.
COMMENT This paper describes the detailed structure of a membrane-embedded aspartyl protease called Flak, a preflagellin peptidase (PFP) from an extremophile that has been categorized as a "GXGD aspartyl protease," along with presenilin and SPP. As this
David Holtzman on Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
COMMENT I want to thank Lars Nilsson for his comments on our recent paper. I think it is important to point out that in the paper by Castellano et al., we demonstrate that human ApoE isoforms differentially influence endogenous Aβ clearance. However, we do not sh
ApoE, ApoE Receptors & Neurodegeneration, 2011
CONFERENCE COVERAGE SERIES Chicago: 2nd Annual Symposium Explores ApoE ApoE, ApoE Receptors & Neurodegeneration, 2011
PAPER Daley GQ, Scadden DT
Prospects for stem cell-based therapy.
Cell. 2008 Feb 22;132(4):544-8. PubMed: 18295571PAPER Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R
Genetic engineering of human pluripotent cells using TALE nucleases.
Nat Biotechnol. 2011 Aug;29(8):731-4. PubMed: 21738127PAPER Summers KM
Relationship between genotype and phenotype in monogenic diseases: relevance to polygenic diseases.
Hum Mutat. 1996;7(4):283-93. PubMed: 8723677PAPER Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.
Cell. 2011 Feb 4;144(3):439-52. PubMed: 21295703Chicago: 2nd Annual Symposium Explores ApoE
CONFERENCE COVERAGE 2011-07-26 Conference Coverage Download a PDF of this report. Apolipoprotein E (ApoE) gene alleles are the strongest genetic modulators of late-onset Alzheimer's disease (AD) risk. Some 60 percent of AD individuals carry at least one copy of the ApoE4 variant.
Editing Stem Cell DNA to Make the Perfect Cells for Study, Therapy
RESEARCH NEWS 2011-07-26 Research News Now that they can make induced pluripotent stem cells from anyone, scientists are near-giddy with excitement over the potential to model diseases in cell lines, as well as someday correct genetic mutations in people (see ARF news series). Bu
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