Neurodegeneration and Aging: Could MicroRNA Be the Link?

RESEARCH NEWS 2012-02-17 Research News Aging is one of the biggest risk factors for neurodegenerative disease, but the biological link between the two processes is unclear. Enter miR-34—a tiny piece of RNA of 21 to 24 nucleotides long. A microRNA, miR-34 binds to certain messenge

PAPER Ihle A, Bunce D, Kliegel M

APOE ε4 and cognitive function in early life: A meta-analysis.

Neuropsychology. 2012 May;26(3):267-77. PubMed: 22329498

PAPER Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B

Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders.

Curr Alzheimer Res. 2012 Jan;9(1):5-17. PubMed: 22329649

PAPER de la Monte SM

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):35-66. PubMed: 22329651

PAPER Carroll JC, Rosario ER

The potential use of hormone-based therapeutics for the treatment of Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):18-34. PubMed: 22329650

PAPER Howes MJ, Houghton PJ

Ethnobotanical treatment strategies against Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):67-85. PubMed: 22329652

PAPER Stranahan AM, Martin B, Maudsley S

Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):86-92. PubMed: 22329653

PAPER Stranahan AM

Chronobiological approaches to Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):93-8. PubMed: 22329654

PAPER Chadwick W, Mitchell N, Martin B, Maudsley S

Therapeutic targeting of the endoplasmic reticulum in Alzheimer's disease.

Curr Alzheimer Res. 2012 Jan;9(1):110-9. PubMed: 22329655

PAPER Lanuti P, Ciccocioppo F, Bonanni L, Marchisio M, Lachmann R, Tabet N, Pierdomenico L, Santavenere E, Catinella V, Iacone A, Thomas A, Gambi D, Miscia S, Onofrj M, Kern F

Amyloid-specific T-cells differentiate Alzheimer's disease from Lewy body dementia.

Neurobiol Aging. 2012 Feb 11; PubMed: 22330173

PAPER Babenko O, Kovalchuk I, Metz GA

Epigenetic programming of neurodegenerative diseases by an adverse environment.

Brain Res. 2012 Mar 20;1444:96-111. PubMed: 22330722

PAPER Miralbell J, Spulber G, Hooshmand B, Besga A, Mataró M, Cedazo-Minguez A, Kivipelto M, Wahlund LO

Grey Matter and Cognitive Patterns in Cognitive Impaired Subjects Using CSF Biomarker Cut-Offs.

J Alzheimers Dis. 2012 Jan 1;29(4):741-9. PubMed: 22330819

PAPER Palmer JC, Barker R, Kehoe PG, Love S

Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated by Amyloid-β.

J Alzheimers Dis. 2012 Jan 1;29(4):853-61. PubMed: 22330820

PAPER Kehoe PG, Passmore PA

The Renin-Angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the Angiotensin hypothesis?

J Alzheimers Dis. 2012;30 Suppl 2:S251-68. PubMed: 22330821

PAPER Lee YT, Pai MC

Recognition of personally familiar scenes in patients with very mild Alzheimer's disease: effects of spatial frequency and luminance.

J Alzheimers Dis. 2012;29(2):441-8. PubMed: 22330822