Stephen Strittmatter on Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice.
COMMENT A growing body of literature supports a key role of cellular prion protein (PrPc) in Alzheimer's pathophysiology. Recent reports have demonstrated that endogenous Aβ oligomers from both mouse and human AD brain bind PrPc, and that PrPc is required fo