RESEARCH NEWS 2014-12-22 Research News Neurons respond awkwardly when astrocytes shower them with too many complements. According to a study in the December 18 Neuron online, astrocytes pump out the complement protein C3 in response to Aβ, and neurons react to the complement by ...
PAPER Lian H, Yang L, Cole A, Sun L, Chiang ACA, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, and Zheng H
Neuron. Published online December 18, 2014.
Analytik JenaJena, Germany
CONFERENCE COVERAGE 2014-12-22 Conference Coverage Researchers agree that a disease as complex as Alzheimer’s may require combination therapies, but so far, few trials have taken on this challenge. That may soon change. At the 7th Clinical Trials on Alzheimer’s Disease (CTAD) ...
PAPER Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, Jiang W, Singer C, Horn S, Pfeiffer R, Rottenberg D, Slevin J, Elmer L, Press D, Hyson HC, McDonald W, SAD-PD Study Group
Neurology. 2012 Apr 17;78(16):1229-36. Epub 2012 Apr 11 PubMed: 22496199
RESEARCH MODELS Summary The tau264 transgenic model expresses low levels of wild-type human tau. This mouse does not develop neuropathology or behavioral deficits. The phenotype information described on this page refers to heterozygous animals. Transgene expression in ...
PAPER Duffy JP, Harrington EM, Salituro FG, Cochran JE, Green J, Gao H, Bemis GW, Evindar G, Galullo VP, Ford PJ, Germann UA, Wilson KP, Bellon SF, Chen G, Taslimi P, Jones P, Huang C, Pazhanisamy S, Wang YM, Murcko MA, Su MS
ACS Med Chem Lett. 2011 Oct 13;2(10):758-63. Epub 2011 Jul 28 PubMed: 24900264