Albrecht Stöffler on Q&A With Ryan Watts, Genentech Lead Scientist on API Trial

COMMENT I would like to thank Ryan Watts for a remark that is not directly linked to this very interesting project but that, nevertheless, I find important for the overall research landscape in AD: When he comments on the general trend for "going early,"

Takaomi Saido on Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients.

COMMENT This is a very important work. 0 saido

Takaomi Saido on Convection-Enhanced Delivery of Neprilysin: A Novel Amyloid-β-Degrading Therapeutic Strategy.

COMMENT The "convection-enhanced delivery" is an interesting idea. 0 saido

Takaomi Saido on The complement system: an unexpected role in synaptic pruning during development and disease.

COMMENT Good to know. 0 saido

Takaomi Saido on Aggregate Clearance of α-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome.

COMMENT Reasonable! 0 saido

Takaomi Saido on Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models.

COMMENT Useful. 0 saido

Bridget Galdes

BiogenIdec
Cambridge, United States

Steven Finkbeiner on ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.

COMMENT I think the overall idea is quite interesting. In a nutshell, it is that TDP-43 normally shuttles between the nucleus and the cytoplasm. Under stress, it moves temporarily to the cytoplasm to form stress granules to help cells cope with the stress. Versio

PAPER Wiedemeyer R, Westermann F, Wittke I, Nowock J, Schwab M

Ataxin-2 promotes apoptosis of human neuroblastoma cells.

Oncogene. 2003 Jan 23;22(3):401-11. PubMed: 12545161

PAPER Hart MP, Gitler AD

ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.

J Neurosci. 2012 Jul 4;32(27):9133-42. PubMed: 22764223

William Cowan

None
Houston, United States

Communication Breakdown: Multiple Networks Decline in AD Brains

RESEARCH NEWS 2012-07-11 Research News A healthy brain switches between its different functional networks like a well-oiled machine, but as dementia takes over, communication becomes disorganized. Connections sputter, and once-sharp distinctions between networks blur, according t

For FTD Drug Development, a Q&A With Regulators

CONFERENCE COVERAGE 2012-07-11 Conference Coverage In advance of a 4 June meeting in Washington, D.C., with regulators and industry scientists, Adam Boxer of the University of California, San Francisco, and other steering committee members from the Frontotemporal Degeneration Study Gro

ALS-Linked Ataxin Repeats Stick It to TDP-43 in Stressed Cells

RESEARCH NEWS 2012-07-11 Research News Having a few excess polyglutamine codons—but not a lot—in the gene ataxin-2 predisposes a person to amyotrophic lateral sclerosis, and scientists are just starting to figure out how. In the July 4 Journal of Neuroscience, Michael Hart of the

PAPER Ondo WG

Tetrabenazine treatment for stereotypies and tics associated with dementia.

J Neuropsychiatry Clin Neurosci. 2012 Mar 1;24(2):208-14. PubMed: 22772669