Gregory A. Petsko

Brandeis University
Waltham, United States

Tjakko Van Ham

Erasmus University Medical Center
Rotterdam, Netherlands

Rafael Gonzalez

San Francisco, United States

Judith Glassgold

Library of Congress
Washington, United States

Suet Theng Beh

�
Taiping, Malaysia

Zvonimir Katusic

Mayo Clinic
Rochester, United States

On Risk, Benefit, and More, Prevention Initiatives Take Questions

CONFERENCE COVERAGE 2012-08-08 Conference Coverage At the Alzheimer’s Association International Conference, held 14-19 July 2012, leaders of three ongoing preclinical treatment initiatives answered questions from a packed audience and from moderator Howard Feldman of the University of

Clinical Trials of Intravenous Bapineuzumab Halted

RESEARCH NEWS 2012-08-08 Research News Janssen Alzheimer Immunotherapy will discontinue all studies of intravenous bapineuzumab, an amyloid-β antibody, in patients with mild to moderate Alzheimer’s disease, according to August 6 press releases by Pfizer and Johnson & Johnson,

PAPER Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

J Clin Invest. 2012 Sep 4;122(9):3063-87. PubMed: 22863620

PAPER Zappettini S, Grilli M, Olivero G, Mura E, Preda S, Govoni S, Salamone A, Marchi M

Beta Amyloid Differently Modulate Nicotinic and Muscarinic Receptor Subtypes which Stimulate in vitro and in vivo the Release of Glycine in the Rat Hippocampus.

Front Pharmacol. 2012;3:146. PubMed: 22866037

PAPER Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

J Neurosci. 2012 May 30;32(22):7454-65. PubMed: 22649225

PAPER Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Rivière JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupré N, Bernard G, Chouinard S, Dion PA, Rouleau GA

Exome sequencing identifies FUS mutations as a cause of essential tremor.

Am J Hum Genet. 2012 Aug 10;91(2):313-9. PubMed: 22863194

PAPER Mittag F, Büchel F, Saad M, Jahn A, Schulte C, Bochdanovits Z, Simón-Sánchez J, Nalls MA, Keller M, Hernandez DG, Gibbs JR, Lesage S, Brice A, Heutink P, Martinez M, Wood NW, Hardy J, Singleton AB, Zell A, Gasser T, Sharma M

Use of support vector machines for disease risk prediction in genome-wide association studies: Concerns and opportunities.

Hum Mutat. 2012 Jul 6; PubMed: 22777693

PAPER Lozada AF, Wang X, Gounko NV, Massey KA, Duan J, Liu Z, Berg DK

Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.

J Neurosci. 2012 May 30;32(22):7651-61. PubMed: 22649244

PAPER Perrier A, Peschanski M

How can human pluripotent stem cells help decipher and cure Huntington's disease?

Cell Stem Cell. 2012 Aug 3;11(2):153-61. PubMed: 22862942