Christian Lobsiger on Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.

COMMENT This new study by the lab of Jeffrey Macklis assesses if, beside the well-established degeneration of (lower) spinal cord motor neurons in the widely used mutant SOD1/G93A mouse line, there is also a loss of (upper) corticospinal motor neurons (CSMNs), as

Christian Lobsiger

Université Pierre et Marie Curie
PARIS cedex 13, France

PAPER Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ

A comparative study of Lrrk2 function in primary neuronal cultures.

Parkinsonism Relat Disord. 2010 Dec;16(10):650-5. PubMed: 20850369

PAPER Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

J Neurosci. 2009 Nov 4;29(44):13971-80. PubMed: 19890007

Jesus Avila on The acetylation of tau inhibits its function and promotes pathological tau aggregation.

COMMENT From a single human gene, many different forms of tau protein could arise. Some of these forms come from alternative splicing of the nuclear RNA transcript, but other forms are the consequence of a post-translational modification—phosphorylation. Recently

Barcelona: What Lies Beyond Genomewide Association Studies?

CONFERENCE COVERAGE 2011-03-29 Conference Coverage The common late-onset forms of Alzheimer’s and Parkinson’s disease are now believed to involve substantial inherited risk. With the use of increasingly large genomewide association studies (GWAS), scientists are making headway dissecti

M. Paul Murphy on Barcelona: 10th AD/PD Conference Hosts a Shaken, Restive Field

COMMENT The AD/PD conference is a unique mixture of researchers in neurodegenerative disease from around the world. The science is always great, and so is the location. Looking forward to seeing everyone in Florence in 2013! mpmurp3 0

Lilian Shelton

United States

PAPER Baláz M, Srovnalová H, Rektorová I, Rektor I

The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.

Exp Brain Res. 2010 Jun;203(2):317-27. PubMed: 20379704

Barcelona: Taking Parkinson’s Research From Movement to Mind

CONFERENCE COVERAGE 2011-03-28 Conference Coverage Parkinson’s disease not only freezes up movement. Scientists are becoming increasingly aware of what the disorder does to the mind as well. A symposium at the 10th International Conference on Alzheimer’s and Parkinson’s Diseases, held

PAPER Rektorova I, Srovnalova H, Kubikova R, Prasek J

Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease.

Mov Disord. 2008 Aug 15;23(11):1580-7. PubMed: 18618663

PAPER Lee JE, Park HJ, Song SK, Sohn YH, Lee JD, Lee PH

Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease.

Neurology. 2010 Nov 30;75(22):2009-16. PubMed: 21115956

PAPER Rektor I, Goldemund D, Sheardová K, Rektorová I, Michálková Z, Dufek M

Vascular pathology in patients with idiopathic Parkinson's disease.

Parkinsonism Relat Disord. 2009 Jan;15(1):24-9. PubMed: 18403246

PAPER Nobili F, Abbruzzese G, Morbelli S, Marchese R, Girtler N, Dessi B, Brugnolo A, Canepa C, Drosos GC, Sambuceti G, Rodriguez G

Amnestic mild cognitive impairment in Parkinson's disease: a brain perfusion SPECT study.

Mov Disord. 2009 Feb 15;24(3):414-21. PubMed: 19235928

PAPER Lyoo CH, Jeong Y, Ryu YH, Rinne JO, Lee MS

Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment.

Eur Neurol. 2010;64(2):65-73. PubMed: 20606450