PAPER Alonso-Nanclares L, Merino-Serrais P, Gonzalez S, Defelipe J

Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopy.

J Neuropathol Exp Neurol. 2013 May;72(5):386-95. PubMed: 23584198

PAPER Bennett RE, Esparza TJ, Lewis HA, Kim E, Mac Donald CL, Sullivan PM, Brody DL

Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice.

J Neuropathol Exp Neurol. 2013 May;72(5):396-403. PubMed: 23584199

PAPER Alves L, Simões MR, Martins C, Freitas S, Santana I

Premorbid IQ influence on screening tests' scores in healthy patients and patients with cognitive impairment.

J Geriatr Psychiatry Neurol. 2013 Jun;26(2):117-26. PubMed: 23584853

PAPER Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.

J Biol Chem. 2013 May 24;288(21):15418-29. PubMed: 23585562

PAPER Tang Z, Bereczki E, Zhang H, Wang S, Li C, Ji X, Branca RM, Lehtiö J, Guan Z, Filipcik P, Xu S, Winblad B, Pei JJ

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis: IMPLICATION FOR ALZHEIMER DISEASE.

J Biol Chem. 2013 May 31;288(22):15556-70. PubMed: 23585566

PAPER Tomita T, Iwatsubo T

Structural biology of presenilins and signal peptide peptidases.

J Biol Chem. 2013 May 24;288(21):14673-80. PubMed: 23585568

PAPER Youdim MB

Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.

Exp Neurobiol. 2013 Mar;22(1):1-10. PubMed: 23585716

PAPER Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL

AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease.

Exp Neurobiol. 2013 Mar;22(1):31-7. PubMed: 23585720

PAPER Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.

PLoS Biol. 2013;11(4):e1001532. PubMed: 23585733

PAPER Marshall GA, Amariglio RE, Sperling RA, Rentz DM

Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease?

Neurodegener Dis Manag. 2012 Oct 1;2(5):483-491. PubMed: 23585777

Miguel Rodríguez-Manotas on Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

COMMENT This paper opens a new way to fight AD. It breaks the paradigm in the sense that upregulating, but not inhibiting, presenilin leads to decreased Aβ42 levels. 0 mmanotas

Andrew Sutton on Quick-and-Early IVIG Therapy: Hints of Promise?

COMMENT This result makes me wonder if there is overlap between IVIG and colostrum, because the latter contains many antibodies, and in the case of Colostrinin®, also proline-rich peptides (PRP). Researchers at the University of Texas Medical Branch at Galveston

S. Choon Tay on In Pursuit of Toxic Tau

COMMENT Most protein aggregation follows sigmoid kinetics. Likewise, tau initially aggregates slowly, but ultimately will accelerate exponentially irrespective of whether there is the presence of β amyloid. tayschoon 0

Irene Knuesel on Like Star Born of Supernova, Plaque Born of Exploded Neuron?

COMMENT We see strikingly similar immunoreactive signals in brain sections from 15-month-old immune-challenged transgenic mice (3xTgAD and ArcAβ lines) and in postmortem AD samples using anti-APP (22C11) and anti-Aβ1-40/42 antibodies, which label dystrophic neuri

PAPER Mazzini A, Incerti M, Favilla R

Interaction of DAPI with pepsin as a function of pH and ionic strength.

Biophys Chem. 1997 Sep 1;67(1-3):65-74. PubMed: 9397519