PAPER Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

J Biol Chem. 2012 Jan 6;287(2):1100-11. PubMed: 22086926

Atul Upadhyay

Japan

Susan Larsson

United States

Grace Huang

United States

Jan Pedersen on Time to Take the "Phospho" out of Tau?

COMMENT The localization data generated with Dendra2 are fascinating. It could be interesting to use the experiment to corroborate the postulate from Hoover et al. that pathological tau is relocalized (accumulated in) to dendrites. jatp 0 Tau mislocalization to d

J. Lucy Boyd on The 2011 Alzforum Awards

COMMENT Kudos to each of these outstanding scientists. Thank you, Alzforum, for bringing attention to the work of Dr. Itzhaki and many others. FNightingale512 0

Tara Spires-Jones on Monomeric Aβ’s Disappearing Act in AD Brain: Two Theories

COMMENT These are two very interesting papers discussing the production of Aβ with age. Soyon Hong and Dennis Selkoe's work in awake, behaving mice is particularly interesting as it elegantly shows that dense plaques are in equilibrium with soluble Aβ in the

PAPER Gatz M, Mortimer JA, Fratiglioni L, Johansson B, Berg S, Reynolds CA, Pedersen NL

Potentially modifiable risk factors for dementia in identical twins.

Alzheimers Dement. 2006 Apr;2(2):110-7. PubMed: 19595867

PAPER Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A

Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.

N Engl J Med. 1986 Nov 13;315(20):1241-5. PubMed: 2430180

Ghafour Ghafari

United States

Whence and Where To: History and Future of AD Therapy Trials

CONFERENCE COVERAGE 2011-11-17 Conference Coverage Paul Aisen heads the Alzheimer's Disease Cooperative Study (ADCS), a federally funded clinical trials consortium headquartered at the University of California, San Diego. The ADCS hosted the 4th International Conference on Clinica

PAPER Perez DL, Larvie M, Acar D, Daffner K

Teaching NeuroImages: apathetic variant of frontotemporal dementia.

Neurology. 2011 Nov 15;77(20):e117. PubMed: 22084280

PAPER Homma T, Mochizuki Y, Mizutani T

Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.

Neuropathology. 2011 Nov 14; PubMed: 22082318

PAPER Swarup V, Phaneuf D, Dupré N, Petri S, Strong M, Kriz J, Julien JP

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.

J Exp Med. 2011 Nov 21;208(12):2429-47. PubMed: 22084410

PAPER Sindreu C, Storm DR

Modulation of neuronal signal transduction and memory formation by synaptic zinc.

Front Behav Neurosci. 2011;5:68. PubMed: 22084630