PAPER Sandoval KE, Farr SA, Banks WA, Niehoff ML, Morley JE, Crider AM, Witt KA

Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice.

Eur J Pharmacol. 2011 Mar 1;654(1):53-9. PubMed: 21185826

PAPER Yun S, Guy HR

Analysis of the stabilities of hexameric amyloid-β(1-42) models using discrete molecular dynamics simulations.

J Mol Graph Model. 2011 Feb;29(5):657-62. PubMed: 21186130

PAPER Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

Brain. 2011 Jan;134(Pt 1):258-77. PubMed: 21186265

PAPER van der Flier WM, Pijnenburg YA, Fox NC, Scheltens P

Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele.

Lancet Neurol. 2011 Mar;10(3):280-8. PubMed: 21185234

Smith Williams

United States

SIRT1 (10E4)

ANTIBODY monoclonal 10E4 manufacturer Cat# 04-1557 Immunogen = His-tagged recombinant protein corresponding to human SIRT1; mouse sequence is 100% identical to immunogen liquid, purified, Tris-Glycine, saline, azide recognizes SIRT1 but not mouse in IH. IgG,κ Sirt

Sir2/SIRT1 (10E4)

ANTIBODY monoclonal 10E4 manufacturer Cat# 04-1091 Immunogen = synthetic peptide corresponding to residues near C-terminus and before Ala-rich domain of human Sir2 liquid, Tris-Glycine, saline, BSA, glycrol, azide recognizes SIRT1(~110 kDa by WB); does not cross-r

Gunnar Gouras on Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.

COMMENT Reply to comment by Sam Gandy and John Steele I appreciate the interest in intraneuronal Aβ by Gandy and Steele, who have been contributing to this topic. I also welcome the comment, because interaction and questioning is so important. Yes, it has been a

William Klunk on Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.

COMMENT This manuscript describes in detail the postmortem assessment of an AD patient studied twice with PIB-PET and three times with FDG-PET during life (last PIB 35 months before death). The subject happens to be the first patient ever studied with PIB-PET, an

Stephen D. Ginsberg on Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.

COMMENT This case report study of the first Pittsburgh Compound B (PIB) positron emission tomography patient with Alzheimer’s disease (AD) by Kadir et al. provides extensive descriptive information regarding the neuropathological changes found in the brain of a 6

Einar Sigurdsson on Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.

COMMENT We thank Rakez for his comment. Antibody response towards non-phosphorylated regions of the immunogen can be expected considering its length and immunogenicity. This should not cause major concerns, as we address in the fourth paragraph of the Discussion

Ian Roberts on San Diego: TDP-43 Targets Loom Large—But Where’s the Bull’s Eye?

COMMENT This is interesting, especially the viral genome theories. References: Martin. subrosa3 0

Nunzio Pomara on Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

COMMENT Prion-like behavior of amyloid-β or corticosterone-induced cerebral β-amyloidosis? Eisele and colleagues (1) reported increased cerebral amyloidosis in amyloid precursor protein (APP) transgenic (tg) mice after intraperitoneal inoculation with β-amyloid-r

PAPER Rivest S

Interactions between the immune and neuroendocrine systems.

Prog Brain Res. 2010;181:43-53. PubMed: 20478432

George Perry on Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver

COMMENT Those working and playing with Mark had a special knowledge, the secret of his superhuman power to get things done. It was simple: generosity of spirit, intellect and effort, all hidden under a legendary sense of humor and love of life. Mark supported eve