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330059 RESULTS

APPPS1

RESEARCH MODELS Summary APPPS1 mice contain human transgenes for both APP bearing the Swedish mutation and PSEN1 containing an L166P mutation, both under the control of the Thy1 promoter. In these mice, expression of the human APP transgene is approximately 3-fold higher

APPDutch

RESEARCH MODELS Summary This transgenic mouse line bears a mutation that was determined to cause hereditary cerebral hemorrhage with amyloidosis-Dutch type, a rare autosomal dominant disorder characterized by cerebral amyloid angiopathy (CAA), strokes, and dementia. APPD

ADanPP

RESEARCH MODELS This transgenic line bears a mutation that causes Familial Danish Dementia (FDD), a rare autosomal dominant disorder characterized by cerebral deposition of Danish-amyloid (ADan), neuro-inflammation, and neurofibrillary tangles (Vidal et al., 2000). The F

Tg-ArcSwe

RESEARCH MODELS Summary The inclusion of the Arctic mutation along with the Swedish mutation in the transgene results in more prominent Aβ pathology, including elevated soluble Aβ aggregates such as Aβ protofibrils, greater accumulation of Aβ inside neurons, and more rob

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