PAPER Kortekaas R, Leenders KL, van Oostrom JC, Vaalburg W, Bart J, Willemsen AT, Hendrikse NH
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Richard Sauerheber on Paper Alert: Intranasal Insulin Data Fuels Push for Phase 2B Trial
COMMENT As an insulin research scientist of many decades, it is of interest to read the article showing alterations in brain function by nasal insulin. For many years, it has been believed that brain tissue as an obligatory glucose consumer does not require insul
Takaomi Saido on Resolving controversies on the path to Alzheimer's therapeutics.
COMMENT We should learn from the success of the vaccination against cervical cancer. 0 saido
Takaomi Saido on Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
COMMENT This is an important paper. 0 saido
Takaomi Saido on Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence.
COMMENT What about plasmin and plasminogen activators? 0 saido
Bruno Bulic on Novel γ-secretase enzyme modulators directly target presenilin protein.
COMMENT Comment by Sascha Weggen, Thorsten Jumpertz, Andreas Rennhack, Bruno Bulic Despite substantial progress in the chemical and preclinical development of γ-secretase modulators (GSMs), the molecular mechanism and target of GSMs have remained controversial. T
Robert Tycko on Will The Toxic Aβ Structure Please Stand Up?
COMMENT This paper from the Eisenberg group suggests several molecular structural models for fibrils formed by full-length β amyloid peptides, based on their crystal structures of segments of the full-length peptide that reveal the details of intermolecular inter
Ron Cialic
Tel Aviv Medical CenterTel Aviv, Israel
Boosting ABC Transporter Helps AD Mice Clear Brain Aβ
RESEARCH NEWS 2011-09-19 Research News It’s not that Alzheimer’s disease patients make too much brain Aβ; they’re slow at purging it—but why? Research published online September 1 in the Journal of Clinical Investigation suggests that ATP binding cassette (ABC) transporters may b
PAPER Murayama S
Clinical and pathological characteristics of FUS/TLS-associated amyotrophic lateral sclerosis (ALS).
Rinsho Shinkeigaku. 2010 Nov;50(11):948-50. PubMed: 21921522PAPER Bak TH
Learning from History-FTD, ALS and Behaviour.
Rinsho Shinkeigaku. 2010 Nov;50(11):1013. PubMed: 21921548PAPER Ichikawa H
Language in ALS/FTLD.
Rinsho Shinkeigaku. 2010 Nov;50(11):1014-6. PubMed: 21921549PAPER Takahata K, Mimura M
Acquired Savant syndrome in frontotemporal dementia.
Rinsho Shinkeigaku. 2010 Nov;50(11):1017. PubMed: 21921550PAPER Yokota O