PAPER Gabelle A, Dumurgier J, Vercruysse O, Paquet C, Bombois S, Laplanche JL, Peoc'h K, Schraen S, Buée L, Pasquier F, Hugon J, Touchon J, Lehmann S
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PAPER Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE
Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons.
J Biol Chem. 2013 Jan 18;288(3):1856-70. PubMed: 23188818Fernando Vieira on An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
COMMENT This is an interesting and potentially very insightful paper by Stephane Pelletier and colleagues exploring the role of the COPI-associated protein pseudokinase Scyl1 in mammalian development and in motor neuronal health and survival. This avenue of resea
Michael Heneka on Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
COMMENT Microglial Cytokines Light the Fire—Interleukin 12-, Interleukin 23-Mediated Inflammation May Act as Driving Force Behind Disease Progression The paper by vom Berg and colleagues further strengthens the hypothesis that innate immune reactions may strongly
Eloise Hudry on Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.
COMMENT Astrocytes as New Therapeutic Targets in Alzheimer’s Disease This study by Jennifer Furman and Christopher Norris and colleagues at the University of Kentucky reports that inhibiting astrocytic activation in a mouse model of Alzheimer’s disease (AD) might
Amelie K. Gubitz on An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
COMMENT Pelletier and colleagues demonstrate that mice deficient in Scyl1 may be a new model for early onset progressive motor neuron disease with some features reminiscent of amyotrophic lateral sclerosis (ALS). The study confirms previous work by Schmidt et al.
Gunnar Gouras on The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
COMMENT Lauritzen et al. provide important new insights into age-related changes in APP fragments within neurons of the triple transgenic mouse. They show interesting early and age-related elevations in APP C-terminal fragments (CTFs), but not full-length APP, in
PAPER High KA, Aubourg P
rAAV human trial experience.
Methods Mol Biol. 2011;807:429-57. PubMed: 22034041PAPER Ogata K, Sato K, Tahirov TH, Tahirov T
Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar.
Curr Opin Struct Biol. 2003 Feb;13(1):40-8. PubMed: 12581658PAPER Crabtree GR, Schreiber SL
SnapShot: Ca2+-calcineurin-NFAT signaling.
Cell. 2009 Jul 10;138(1):210, 210.e1. PubMed: 19596245PAPER Nagamoto-Combs K, Combs CK
Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells).
J Neurosci. 2010 Jul 14;30(28):9641-6. PubMed: 20631193PAPER Clipstone NA, Crabtree GR
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation.
Nature. 1992 Jun 25;357(6380):695-7. PubMed: 1377362PAPER Schmidt WM, Kraus C, Höger H, Hochmeister S, Oberndorfer F, Branka M, Bingemann S, Lassmann H, Müller M, Macedo-Souza LI, Vainzof M, Zatz M, Reis A, Bittner RE
Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration.
EMBO Rep. 2007 Jul;8(7):691-7. PubMed: 17571074PAPER Chafe SC, Mangroo D
Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex.
Mol Biol Cell. 2010 Jul 15;21(14):2483-99. PubMed: 20505071Amelie K. Gubitz
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