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John Morley

Canada

Jose López

USAT College of Medicine
United States

John Cirrito on Synaptic autoregulation by metalloproteases and γ-secretase.

COMMENT Restituito and colleagues provide interesting and compelling evidence that α-secretase/matrix metalloproteases (MMPs) and γ-secretase lead to a suppression of synaptic activity. NMDA receptors increase enzymatic activity of α-secretase. α-secretase cleave

Anastasios Georgakopoulos on Synaptic autoregulation by metalloproteases and γ-secretase.

COMMENT The interesting work by Restituito et al. shows that both metalloproteinase and γ-secretase activities are localized at the synapse and regulate synaptic function. These findings, combined with previous reports that PS1 FAD mutations cause loss of γ-secre

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