COMMENT I agree with Li-Huei Tsai; we were surprised too. As rightly indicated, H2AX can become phosphorylated by other nervous system kinases, such as DNA-PK, which could compensate in the absence of efficient DNA repair signalling by ATM in the context of ...
CONFERENCE COVERAGE 2017-07-21 Conference Coverage Researchers convened last month in Heidelberg, Germany, could have been forgiven for thinking they had been teleported back to AD research of the 1990s. Classic, good old biochemistry captured the limelight at Mechanisms in ...
Director of Research Sheffield, United Kingdom
PAPER Biermann B, Ivankova-Susankova K, Bradaia A, Abdel Aziz S, Besseyrias V, Kapfhammer JP, Missler M, Gassmann M, Bettler B20107064
CONFERENCE 2018-02-23 00:00:00-2018-02-24 00:00:00 San Juan, Puerto Rico 23 – 24 February 2018 Diagnosis, prevention, and the care provided to individuals with Alzheimer's disease are greatly influenced by socioeconomic and cultural factors. Statistics suggest that the incidence of ...
Washington University in St. LouisSt. Louis, United States
Chan Zuckerberg InitiativeUnited States
COMMENT This study is consistent with our previous work on the relationship of accumulation of DNA damage and neurodegeneration. In our paper published in 2013 in Nature Neuroscience (Wang et al.), we showed that the familial ALS gene product, FUS, a DNA/RNA ...
RESEARCH NEWS 2017-07-21 Research News Hexanucleotide expansions in the C9ORF72 gene—the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia—mount a multipronged attack on the DNA repair system, according to a July 17 study in Nature ...
PAPER Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, Li X, Wang L, Wang J, Zhang H, Gu W, Zhu WG, Zhao Y
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.Mol Cell. 2016 Jul 7;63(1):34-48. Epub 2016 Jun 23 PubMed: 27345151
PAPER Lee JH, Goodarzi AA, Jeggo PA, Paull TT20010693
PAPER Hamperl S, Cimprich KA
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.DNA Repair (Amst). 2014 Jul;19:84-94. Epub 2014 Apr 18 PubMed: 24746923
PAPER Aguilera A, García-Muse T22541554
VUMC AmsterdamUtrecht, Netherlands
PAPER Simpraga S, Alvarez-Jimenez R, Mansvelder HD, van Gerven JM, Groeneveld GJ, Poil SS, Linkenkaer-Hansen K28720796
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