PAPER Ikura T, Ito N

Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating.

Protein Eng Des Sel. 2013 Sep;26(9):539-46. PubMed: 23832849

PAPER Snellman A, López-Picón FR, Rokka J, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M

Longitudinal Amyloid Imaging in Mouse Brain with 11C-PIB: Comparison of APP23, Tg2576, and APPswe-PS1dE9 Mouse Models of Alzheimer Disease.

J Nucl Med. 2013 Aug;54(8):1434-41. PubMed: 23833271

PAPER Lee JE, Han PL

An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.

Exp Neurobiol. 2013 Jun;22(2):84-95. PubMed: 23833557

PAPER Chiò A, Battistini S, Calvo A, Caponnetto C, Conforti FL, Corbo M, Giannini F, Mandrioli J, Mora G, Sabatelli M, , Ajmone C, Mastro E, Pain D, Mandich P, Penco S, Restagno G, Zollino M, Surbone A

Genetic counselling in ALS: facts, uncertainties and clinical suggestions.

J Neurol Neurosurg Psychiatry. 2013 Jul 6; PubMed: 23833266

PAPER Wietek J, Haralampiev I, Amoussouvi A, Herrmann A, Stöckl M

Membrane bound α-synuclein is fully embedded in the lipid bilayer while segments with higher flexibility remain.

FEBS Lett. 2013 Aug 19;587(16):2572-7. PubMed: 23831067

PAPER Donaghy P, Thomas AJ, O'Brien JT

Amyloid PET Imaging in Lewy Body Disorders.

Am J Geriatr Psychiatry. 2013 Jul 3; PubMed: 23831180

PAPER Kim HJ

Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective.

Exp Neurobiol. 2013 Jun;22(2):77-83. PubMed: 23833556

PAPER Fujita KA, Ostaszewski M, Matsuoka Y, Ghosh S, Glaab E, Trefois C, Crespo I, Perumal TM, Jurkowski W, Antony PM, Diederich N, Buttini M, Kodama A, Satagopam VP, Eifes S, Del Sol A, Schneider R, Kitano H, Balling R

Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map.

Mol Neurobiol. 2013 Jul 7; PubMed: 23832570

PAPER Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse.

Neurosci Lett. 2013 Aug 9;549:57-62. PubMed: 23721786

PAPER Jayasena T, Poljak A, Smythe G, Braidy N, Münch G, Sachdev P

The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease.

Ageing Res Rev. 2013 Jul 5;12(4):867-883. PubMed: 23831960

PAPER Okada Y, Okada M

Protective effects of plant seed extracts against amyloid β-induced neurotoxicity in cultured hippocampal neurons.

J Pharm Bioallied Sci. 2013 Apr;5(2):141-7. PubMed: 23833520

Per Westermark

Uppsala Universitet
United States

Barry Ticho

United States

Per Westermark on An Extra Strain on the Brain—α-Synuclein Seeds Tau Aggregation

COMMENT The concept of "strains" emanates from the prion field. It has been shown both in vitro and in animal models that the disease-associated prion protein (PrPsc) can exhibit differences in misfolding and aggregation. These different forms tend to b

APP L705V

MUTATIONS APP 27264132 GRCh37/hg19 rs63750921 C G g.275305C> G g.284001C> G Exon 17 Point, Missense Coding Accelerated nucleation of Aβ aggregates in vitro Severe CAA; Hemorrhages originating from affected vessels; “Vessel-within-vessel” morphology; Absence o