COMMENT Neuroinflammatory mechanisms have emerged as an important feature and pathogenic event in Alzheimer’s disease. Recently, mutations in TREM2 have been identified as risk factors for the development of the sporadic type of this neurodegenerative disease. In ...
PAPER Jung DY, Lee H, Suk K15953367
PAPER Kim SJ, Li J
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.Cell Death Dis. 2013 Jul 11;4:e716. PubMed: 23846218
RESEARCH NEWS 2015-02-28 Research News When the going gets tough, microglia rely on TREM2 to get going. That was the common conclusion from two papers that investigated the role of the myeloid receptor in mouse models of Alzheimer’s disease and stroke. One study, led by Marco ...
PAPER Cannon JP, O'Driscoll M, Litman GW21800138
PAPER Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE12847223
PAPER Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA
PAPER Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, and Colonna M
COMMENT Epigenetics is an exciting and developing field. These papers represent an excellent first step to allow researchers to unravel the epigenetic architecture of diseases such as Alzheimer’s. The epigenomic roadmap provides a platform to advance our ...
RESEARCH NEWS 2015-02-27 Research News A consortium of 258 researchers at 41 institutions, having completed 2,800 experiments and sequenced 150 billion DNA fragments over seven years, now presents the human epigenome. In the February 19 Nature, corresponding author Manolis Kellis ...
RESEARCH NEWS 2015-02-27 Research News Vitae Pharmaceuticals announced on 26 February the temporary suspension of Phase I clinical testing of BI 1181181. This β-secretase (BACE) inhibitor is being developed by Boehringer Ingelheim and evaluated jointly with Vitae. Few details are ...
PAPER Xi Z, Zhang M, Bruni AC, Maletta RG, Colao R, Fratta P, Polke JM, Sweeney MG, Mudanohwo E, Nacmias B, Sorbi S, Tartaglia MC, Rainero I, Rubino E, Pinessi L, Galimberti D, Surace EI, McGoldrick P, McKeever P, Moreno D, Sato C, Liang Y, Keith J, Zinman L, Robertson J, Rogaeva E25716178
PAPER Ziller MJ, Edri R, Yaffe Y, Donaghey J, Pop R, Mallard W, Issner R, Gifford CA, Goren A, Xing J, Gu H, Cacchiarelli D, Tsankov AM, Epstein C, Rinn JL, Mikkelsen TS, Kohlbacher O, Gnirke A, Bernstein BE, Elkabetz Y, Meissner A25533951
PAPER Tsankov AM, Gu H, Akopian V, Ziller MJ, Donaghey J, Amit I, Gnirke A, Meissner A25693565
PAPER Dixon JR, Jung I, Selvaraj S, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B25693564
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