Eric Luth

Brigham and Women’s Hospital/Harvard Medical School
United States

Ulf Dettmer

Harvard Medical School, Brigham and Women’s Hospital
United States

PAPER Black SE

Brain stimulation, learning, and memory.

N Engl J Med. 2012 Feb 9;366(6):563-5. PubMed: 22316451

PAPER Suthana N, Haneef Z, Stern J, Mukamel R, Behnke E, Knowlton B, Fried I

Memory enhancement and deep-brain stimulation of the entorhinal area.

N Engl J Med. 2012 Feb 9;366(6):502-10. PubMed: 22316444

Vincent Marchesi on Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.

COMMENT This paper deals with the question of whether small blood vessel damage is a primary factor in the pathogenesis of AD, an idea advanced years ago that has since been eclipsed by the deluge of experimental data that incriminates amyloid aggregates as the m

Diana Hausman

Seattle, United States

PAPER Klohs J, Baltes C, Princz-Kranz F, Ratering D, Nitsch RM, Knuesel I, Rudin M

Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.

J Neurosci. 2012 Feb 1;32(5):1705-13. PubMed: 22302811

PAPER Buée L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH, Fillit HM

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders.

Acta Neuropathol. 1994;87(5):469-80. PubMed: 8059599

Jack Lenz

United States

Vivian Hook on Not the Usual Suspects: Tracking BACE Inhibition, Axon Role

COMMENT This article by Mattsson et al. is authored by an outstanding group, which investigated the effects of BACE1 inhibitors on Aβ peptide forms in media secreted from cultured neurons and in CSF after in-vivo treatment of dogs. Interestingly, the data suggest

Vivian Hook

University of California, San Diego
San Diego, United States

Ahmad Salehi on Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice.

COMMENT This strategy is very interesting, and, apparently, the mice with Kcnj6 trisomy show similar behavioral abnormalities as those found in the Ts65Dn mouse, which is a widely used mouse model of Down's syndrome. Obviously, there are around 400 other gen

PAPER Cooper A, Grigoryan G, Guy-David L, Tsoory MM, Chen A, Reuveny E

Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice.

Proc Natl Acad Sci U S A. 2012 Jan 30; PubMed: 22308328

Upping Brain ApoE, Drug Treats Alzheimer's Mice

RESEARCH NEWS 2012-02-10 Research News Move over, β amyloid. Here comes apolipoprotein E—target of a potential new Alzheimer’s disease therapy that looks promising in mice. In an online Science paper published yesterday and covered widely in the lay media (see, e.g., National Pub

Computer-Painted Pictures Worth a Thousand Words

RESEARCH NEWS 2012-02-10 Research News Neuroscientists are reaping the benefits of new technological advances in image processing. “The old strategy was to take 40 to 50 images of different regions of the brain at high magnification and then piece them together manually, like a m