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PAPER Flavell SW, Greenberg ME
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system.
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Place navigation impaired in rats with hippocampal lesions.
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Presenilin 1 independently regulates beta-catenin stability and transcriptional activity.
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Aspartate transcarbamylase of Escherichia coli. Mechanisms of inhibition and activation by dicarboxylic acids and other anions.
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The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities.
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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry. 1999 Apr 13;38(15):4720-7. PubMed: 10200159PAPER Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
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Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production.
J Biol Chem. 1999 Mar 26;274(13):8966-72. PubMed: 10085142PAPER Durkin JT, Murthy S, Husten EJ, Trusko SP, Savage MJ, Rotella DP, Greenberg BD, Siman R
Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
J Biol Chem. 1999 Jul 16;274(29):20499-504. PubMed: 10400678PAPER Murayama O, Murayama M, Honda T, Sun X, Nihonmatsu N, Takashima A
Twenty-nine missense mutations linked with familial Alzheimer's disease alter the processing of presenilin 1.
Prog Neuropsychopharmacol Biol Psychiatry. 1999 Jul;23(5):905-13. PubMed: 10509383PAPER Attwell D, Laughlin SB
An energy budget for signaling in the grey matter of the brain.
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Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat.
Science. 1979 Aug 17;205(4407):723-5. PubMed: 462184PAPER Rocher AB, Chapon F, Blaizot X, Baron JC, Chavoix C
Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: a study in baboons.
Neuroimage. 2003 Nov;20(3):1894-8. PubMed: 14642499Current Filters
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