Merav Weinstein

Israel

Philip Van Damme on Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses.

COMMENT In this interesting paper, Tapia et al. describe how knockdown of progranulin in cultured hippocampal neurons gave rise to an impoverished dendritic arborization and spine density, which could be rescued by substituting progranulin. Likewise, the density

Jitin Bali on Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

COMMENT Poly (I:C) Effects on Alzheimer’s Disease—BACE1 and Hence Aβ Dependent? Causes for sporadic Alzheimer’s disease (AD) are often attributed to amyloid-independent pathways, whereas early onset AD clearly follows the mechanism outlined in the amyloid cascade

Steve Foell

United States

Robert Perneczky on Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis.

COMMENT I think that sAPPα and sAPPβ are among the most interesting new biomarkers for a range of neurodegenerative disorders, including ALS and AD. In line with their previous report on this topic, Steinacker et al. clearly show that ALS has a significant impact

Department of Defense Offers Alzheimer’s Research Dollars

COMMUNITY NEWS 2011-09-06 Community News Updated 8 September 2011 to reflect a correction about the content and funding request of the 2011 Alzheimer's Breakthrough Act. Alzheimer’s researchers in the U.S. have felt the pinch of shrinking budgets and reduced National Institut

Are Soluble APP Fragments Markers for ALS?

RESEARCH NEWS 2011-09-06 Research News Readers could be forgiven for doing a double-take at the title of a recent paper linking amyloid precursor protein (APP)—best known for its role in Alzheimer’s disease—to amyotrophic lateral sclerosis (ALS). The authors, led by first author