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Parkinson’s Gene Increases Risk of Dementia

RESEARCH NEWS 2013-04-19 Research News One of the top Parkinson’s disease risk genes, glucocerebrosidase 1 (GBA1), appears to be an even bigger risk factor for the related synucleinopathy dementia with Lewy bodies (DLB), according to a report in the April 15 JAMA Neurology. Resea

Stem Cell Screen Points to ALS Disease Target

RESEARCH NEWS 2013-04-19 Research News Therapies for amyotrophic lateral sclerosis (ALS) have proven hard to develop, in part because of inadequate disease models. A new stem cell-based screening method may help. Researchers led by Lee Rubin, Harvard University, Cambridge, Massac

PAPER Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, Spaltro G, Lidonnici D, Gensano F, Battaglia E, Bendotti C, Bonetto V

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS.

J Biol Chem. 2013 May 31;288(22):15699-711. PubMed: 23592792

PAPER de Tullio MB, Castelletto V, Hamley IW, Martino Adami PV, Morelli L, Castaño EM

Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates.

PLoS One. 2013;8(4):e59113. PubMed: 23593132

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Beta amyloid imaging with positron emission tomography (PET) for evaluation of suspected Alzheimer's disease or other causes of cognitive decline.

Eur Arch Psychiatry Clin Neurosci. 2013 Apr 17; PubMed: 23589929

PAPER Zeng F, Goodman MM

Fluorine-18 radiolabeled heterocycles as PET tracers for imaging β-amyloid plaques in Alzheimer's disease.

Curr Top Med Chem. 2013;13(8):909-19. PubMed: 23590167

PAPER Zhou Y, Wang J, Liu L, Wang R, Lai X, Xu M

Interaction between amyloid-β peptide and heme probed by electrochemistry and atomic force microscopy.

ACS Chem Neurosci. 2013 Apr 17;4(4):535-9. PubMed: 23590249

PAPER Kouyoumdjian H, Zhu DC, El-Dakdouki MH, Lorenz K, Chen J, Li W, Huang X

Glyconanoparticle aided detection of β-amyloid by magnetic resonance imaging and attenuation of β-amyloid induced cytotoxicity.

ACS Chem Neurosci. 2013 Apr 17;4(4):575-84. PubMed: 23590250

PAPER Hilpert H, Guba W, Woltering TJ, Wostl W, Pinard E, Mauser H, Mayweg AV, Rogers-Evans M, Humm R, Krummenacher D, Muser T, Schnider C, Jacobsen H, Ozmen L, Bergadano A, Banner DW, Hochstrasser R, Kuglstatter A, David-Pierson P, Fischer H, Polara A, Narquizian R

β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.

J Med Chem. 2013 May 23;56(10):3980-95. PubMed: 23590342

PAPER Shi S, Wang Z, Qiao Z

The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease.

Curr Med Chem. 2013;20(20):2583-8. PubMed: 23590711

PAPER Menšíková K, Matěj R, Tučková L, Rusina R, Ehrmann J, Kaňovský P

Progressive supranuclear palsy phenotype mimicking synucleinopathies.

J Neurol Sci. 2013 Jun 15;329(1-2):34-7. PubMed: 23590894

PAPER Blanc F

Does cognitive profile distinguish Lewy body disease from Alzheimer's disease in the early stages?

J Neurol Neurosurg Psychiatry. 2013 Apr 16; PubMed: 23591555