COMMENT I think this is an interesting study, as it provides new insights into the mechanism of MN death in ALS. That almost all of the 11 regulators identified are transcription factors suggests that the death of MN involves transcription. These regulators ...
PAPER Kumalo HM, Bhakat S, Soliman ME26208540
PAPER Guerreiro C, Silva B, Crespo ÂC, Marques L, Costa S, Timóteo Â, Marcelino E, Maruta C, Vilares A, Matos M, Couto FS, Faustino P, Verdelho A, Guerreiro M, Herrero A, Costa C, de Mendonça A, Martins M, Costa L
Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients.Biochim Biophys Acta. 2015 Jul 22; PubMed: 26209012
COMMENT The post-translation modifications (PTMs) of tau have long been proposed to play an important role in tau aggregation and tau-mediated neurodegeneration. However, the overall PTMs of tau under physiological conditions are not well elucidated. By using an ...
Harvard Medical SchoolBoston, United States
COMMENT I believe this work has implications for sporadic ALS, because the cytohesin inhibitor SecinH3 does not appear specific for mutant SOD1 but rather limits the downstream consequences of misfolded proteins, which may include ER-stress (based on their work). ...
COMMENT The paper is an elegant piece of work demonstrating, for the first time, the molecular basis of how b-CTF could play a role in the activation of Rab5, a process that is intricately associated with the enlargement of endosomes. Apart from the plaques and ...
Barrow Neurological InstitutePhoenix, United States
PAPER Hawkes N26209691
PAPER Lee RP, Bamford C, Exley C, Robinson L
Expert views on the factors enabling good end of life care for people with dementia: a qualitative study.BMC Palliat Care. 2015 Jul 25;14:32. PubMed: 26208849
PAPER Heurling K, Buckley C, Van Laere K, Vandenberghe R, Lubberink M26209803
PAPER Bourdenx M, Koulakiotis NS, Sanoudou D, Bezard E, Dehay B, Tsarbopoulos A
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Prog Neurobiol. 2015 Jul 21; PubMed: 26209472
BARC Global Central LabScottsdale, United States
PAPER McCartney M26208710
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