Said Ramdane on Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver

COMMENT I am very saddened to learn of the death of Professor Mark Smith. I had the privilege to meet him at three successive ICAD meetings. He had a unique and wonderful personality. The scientific community has lost a giant of medical research on Alzheimer'

Dementia Diagnosis—Are Many Heads Better Than One?

RESEARCH NEWS 2011-01-07 Research News In the absence of a definitive test for Alzheimer’s disease, the diagnosis of dementia remains something of an art, dependent on a clinician’s experience and judgment. The truth of the matter becomes clear only upon pathological examination,

PAPER López-Senín P, Gómez-Pinto I, Grandas A, Marchán V

Identification of Ligands for the Tau Exon 10 Splicing Regulatory Element RNA by Using Dynamic Combinatorial Chemistry.

Chemistry. 2011 Jan 5; PubMed: 21207534

PAPER Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y

Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1681-6. PubMed: 21205885

PAPER Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

J Clin Invest. 2011 Feb;121(2):726-38. Epub 2011 Jan 4 PubMed: 21206091

PAPER Jayadev S, Case A, Eastman AJ, Nguyen H, Pollak J, Wiley JC, Möller T, Morrison RS, Garden GA

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.

PLoS One. 2010;5(12):e15743. PubMed: 21206757

PAPER Patrias LM, Klaver AC, Coffey MP, Finke JM, Digambaranath JL, Dang L, Martinez AA, Loeffler DA

Effects of External-Beam Radiation on In Vitro Formation of Abeta1-42 Fibrils and Preformed Fibrils.

Radiat Res. 2011 Jan 4; PubMed: 21204673

PAPER Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

Biochem J. 2011 Mar 15;434(3):503-12. PubMed: 21204788

PAPER Sheikh AM, Nagai A

Lysophosphatidylcholine modulates fibril formation of amyloid beta peptide.

FEBS J. 2011 Feb;278(4):634-42. PubMed: 21205198

PAPER Mohammadi M, Yazdanparast R

Modulation of H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells by EUK134, a salen derivative.

Basic Clin Pharmacol Toxicol. 2011 Jun;108(6):378-84. PubMed: 21205220

PAPER Sonobe N, Hata R, Ishikawa T, Sonobe K, Matsumoto T, Toyota Y, Mori T, Fukuhara R, Komori K, Ueno SI, Tanimukai S, Ikeda M

Risk of progression from mild memory impairment to clinically diagnosable Alzheimer's disease in a Japanese community (from the Nakayama Study).

Int Psychogeriatr. 2010 Dec 16;:1-8. PubMed: 21205364

PAPER Marchesi VT

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy.

FASEB J. 2011 Jan;25(1):5-13. PubMed: 21205781

PAPER Hauser CA, Deng R, Mishra A, Loo Y, Khoe U, Zhuang F, Cheong DW, Accardo A, Sullivan MB, Riekel C, Ying JY, Hauser UA

Natural tri- to hexapeptides self-assemble in water to amyloid beta-type fiber aggregates by unexpected alpha-helical intermediate structures.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6. PubMed: 21205900

PAPER Chamberlain SR, Blackwell AD, Nathan PJ, Hammond G, Robbins TW, Hodges JR, Michael A, Semple JM, Bullmore ET, Sahakian BJ

Differential cognitive deterioration in dementia: a two year longitudinal study.

J Alzheimers Dis. 2011;24(1):125-36. PubMed: 21206003

PAPER Long LH, Wu PF, Guan XL, Zhang JQ, Jin Y, Zhang Z, Wang Y, Li YY, Chen JG, Wang F

Determination of protein-bound methionine oxidation in the hippocampus of adult and old rats by LC-ESI-ITMS method after microwave-assisted proteolysis.

Anal Bioanal Chem. 2011 Feb;399(6):2267-74. PubMed: 21207014