Jacqueline Carrillo
Richmond, United States
331009 RESULTS
Richmond, United States
COMMENT This study by Matrone et al. establishes a reciprocal, functional link between the post-translational modification of the amyloid-β precursor protein (APP) and the NGF/TrkA signaling pathway that could be relevant to Alzheimer’s disease (AD). This article
COMMENT An interesting piece of work. 0 saido
COMMENT This is an elegant study by the Holtzman group which clearly shows that yet another neurodegenerative disease-associated protein, thought to be cytosolic, is found extracellularly in the brain parenchyma. Using an optimized in-vivo microdialysis approach
IRB BarcelonaBarcelona, Spain
RESEARCH NEWS 2011-10-03 Research News Much as the enzyme superoxide dismutase 1 protects cells from dangerous free radicals, in amyotrophic lateral sclerosis it may succumb to peer pressure, where malformed enzymes convert others to aggregation-prone forms in a twisted game of m
RESEARCH NEWS 2011-10-03 Research News Comfort—it’s what family members want most for their bedridden loved ones with advanced dementia. Yet according to a study in the New England Journal of Medicine, the final days for nursing home residents in this situation are often far from
RESEARCH NEWS 2011-10-03 Research News Though AD pathology is nothing to sniff at, some features, notably neurodegeneration, have been vexingly hard to reproduce in animal models. Researchers at the National Institutes of Health, Bethesda, Maryland, have created a mouse model tha
PAPER Grabowski DC
PAPER Kane RL, Keckhafer G, Flood S, Bershadsky B, Siadaty MS
PAPER Kane RL, Flood S, Bershadsky B, Keckhafer G
PAPER Ouslander JG, Lamb G, Tappen R, Herndon L, Diaz S, Roos BA, Grabowski DC, Bonner A
PAPER Ravits JM, La Spada AR
PAPER Münch C, Bertolotti A
COMMENT Reply to Selkoe Comment In Dr. Selkoe's comment above, he writes: "First, Dr. Lashuel suggested that one should run the denatured recombinant protein side by side with cell extracts. That is just what we did, and showed in Supp. Fig. S5 A and B.
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