PAPER Takahashi Y, Fukuda Y, Yoshimura J, Toyoda A, Kurppa K, Moritoyo H, Belzil VV, Dion PA, Higasa K, Doi K, Ishiura H, Mitsui J, Date H, Ahsan B, Matsukawa T, Ichikawa Y, Moritoyo T, Ikoma M, Hashimoto T, Kimura F, Murayama S, Onodera O, Nishizawa M, Yoshida M, Atsuta N, Sobue G, , Fifita JA, Williams KL, Blair IP, Nicholson GA, Gonzalez-Perez P, Brown RH, Nomoto M, Elenius K, Rouleau GA, Fujiyama A, Morishita S, Goto J, Tsuji S

ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19.

Am J Hum Genet. 2013 Oct 8; PubMed: 24119685

Ahmed Kassem

University of Pittsburgh
United States

Richard Ransohoff on Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage.

COMMENT As far as it goes, this paper is quite provocative. The main limitations are that the experiments were done in artificial cell lines and used transfected molecular components. It should be possible, based on these findings, to demonstrate abnormalities of

PAPER McFarland K, Spalding TA, Hubbard D, Ma JN, Olsson R, Burstein ES

Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease.

ACS Chem Neurosci. 2013 Oct 11; PubMed: 24117438

PAPER Sjölander A, Andersson ME, Zetterberg H, Minthon L, Bogdanovic N, Blennow K

Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk.

Mol Med Rep. 2009 Nov-Dec;2(6):989-92. PubMed: 21475932

PAPER Frontera JA

Blood-pressure lowering in acute intracerebral hemorrhage.

N Engl J Med. 2013 Sep 26;369(13):1275. PubMed: 24073438

PAPER Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey JM,

Evolution and functional impact of rare coding variation from deep sequencing of human exomes.

Science. 2012 Jul 6;337(6090):64-9. PubMed: 22604720

PAPER Bird TD, Koerker RM, Leaird BJ, Vlcek BW, Thorning DR

Lipomembranous polycystic osteodysplasia (brain, bone, and fat disease): a genetic cause of presenile dementia.

Neurology. 1983 Jan;33(1):81-6. PubMed: 6681564

PAPER Johnson B, Zhang K, Gay M, Horovitz S, Hallett M, Sebastianelli W, Slobounov S

Alteration of brain default network in subacute phase of injury in concussed individuals: resting-state fMRI study.

Neuroimage. 2012 Jan 2;59(1):511-8. PubMed: 21846504

PAPER Talavage TM, Nauman EA, Breedlove EL, Yoruk U, Dye AE, Morigaki KE, Feuer H, Leverenz LJ

Functionally-Detected Cognitive Impairment in High School Football Players Without Clinically-Diagnosed Concussion.

J Neurotrauma. 2013 Apr 11; PubMed: 20883154

Dementia Society

Dementia Society, Inc.
Doylestown, United States

Rizki Surya Ningsih

Indonesia

Fall Flurry of Letters Kicks Up Dust Around TREM2

RESEARCH NEWS 2013-10-18 Research News Nearly one year ago, two research groups reported that a mutation in the triggering receptor expressed on myeloid cells 2, better known as TREM2, raises risk for Alzheimer’s disease by nearly as much as does the established risk factor ApoE4

Could Bexarotene Treat Parkinson’s Disease?

RESEARCH NEWS 2013-10-18 Research News A drug currently under investigation as an Alzheimer’s treatment may show promise for Parkinson’s disease as well, suggests a paper in the October 11 ACS Chemical Neuroscience. Bexarotene, an approved cancer drug, made headlines in 2012 when

Study Links Motor Neuron Disease to New Receptor Tyrosine Kinase

RESEARCH NEWS 2013-10-18 Research News Known genetic variants explain only 75 percent of familial amyotrophic lateral sclerosis cases, leaving more ALS genes to find. However, since the largest ALS families already have been scoured by gene-hunters, researchers now resort to stud