Research Brief: VILIP-1 a Potential CSF Marker for AD?

RESEARCH NEWS 2012-03-16 Research News Continued setbacks in Alzheimer’s disease clinical trials have fueled a sense that candidate drugs have been tested in patients whose disease has already progressed too far. For a better shot at their goal, experts say, sponsors should give

PAPER Irish M, Graham A, Graham KS, Hodges JR, Hornberger M

Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia.

Arch Clin Neuropsychol. 2012 May;27(3):338-47. PubMed: 22414677

PAPER Lee S, Kim Y, Li E, Park S

Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation.

Korean J Physiol Pharmacol. 2012 Feb;16(1):43-8. PubMed: 22416219

PAPER Cozzolino M, Pesaresi MG, Gerbino V, Grosskreutz J, Carrì MT

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention.

Antioxid Redox Signal. 2012 Apr 30; PubMed: 22413952

PAPER Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9. PubMed: 22416121

PAPER Rendeiro C, Guerreiro JD, Williams CM, Spencer JP

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects.

Proc Nutr Soc. 2012 May;71(2):246-62. PubMed: 22414320

PAPER La Spada AR

Finding a sirtuin truth in Huntington's disease.

Nat Med. 2012 Jan;18(1):24-6. PubMed: 22227661

PAPER Long JD, Matson WR, Juhl AR, Leavitt BR, Paulsen JS,

8OHdG as a marker for Huntington disease progression.

Neurobiol Dis. 2012 Jun;46(3):625-634. PubMed: 22414782

PAPER Xue S, Chen C, Dong W, Hui G, Liu T, Guo L

Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes.

Sci China Life Sci. 2012 Feb;55(2):132-40. PubMed: 22415684

PAPER Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL

Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients.

Stem Cells. 2012 Jun;30(6):1144-51. PubMed: 22415942

PAPER Blanquer M, Moraleda JM, Iniesta F, Gómez-Espuch J, Meca-Lallana J, Villaverde R, Pérez-Espejo MÁ, Ruíz-López FJ, Santos JM, Bleda P, Izura V, Sáez M, de Mingo P, Vivancos L, Carles R, Jiménez J, Hernández J, Guardiola J, Del Rio ST, Antúnez C, De La Rosa P, Majado MJ, Sánchez-Salinas A, López J, Martínez-Lage JF, Martínez S

Neurotrophic bone marrow cellular nests prevent spinal motoneuron degeneration in amyotrophic lateral sclerosis patients: a pilot safety study.

Stem Cells. 2012 Jun;30(6):1277-85. PubMed: 22415951

PAPER Kim HJ, Jin CY

Stem cells in drug screening for neurodegenerative disease.

Korean J Physiol Pharmacol. 2012 Feb;16(1):1-9. PubMed: 22416213

PAPER Sadli N, Ackland ML, De Mel D, Sinclair AJ, Suphioglu C

Effects of zinc and DHA on the epigenetic regulation of human neuronal cells.

Cell Physiol Biochem. 2012;29(1-2):87-98. PubMed: 22415078

PAPER Rubio JP, Topp S, Warren L, St Jean PL, Wegmann D, Kessner D, Novembre J, Shen J, Fraser D, Aponte J, Nangle K, Cardon LR, Ehm MG, Chissoe SL, Whittaker JC, Nelson MR, Mooser VE

Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.

Hum Mutat. 2012 Jul;33(7):1087-98. PubMed: 22415848

PAPER Matsubara E

[Melatonin agonist: a possible disease-modifying agent for Alzheimer's disease].

Nihon Rinsho. 2012 Feb;70(2):349-52. PubMed: 22413544