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Shielding Synaptic Glutamate Receptor from Aβ Preserves Memory in Mice

RESEARCH NEWS 2016-05-25 Research News Researchers believe Aβ oligomers do much of their dirty work at the synapse. If so, could protecting synaptic receptors from Aβ preserve cognition? In the May 31 Cell Reports, researchers led by Stephen Ferguson at the University of Ottawa ...

PAPER Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. Epub 2015 Feb 9 PubMed: 25665805

Protease World in Health & Disease 2016

CONFERENCE 2016-09-14 00:00:00-2016-09-17 00:00:00 Kiel, Germany 14 &#x2013 17 September 2016 Proteases constitute 1–5 percent of eukaryotic genes and the human genome encodes 588 predicted proteolytic enzymes. The functions of proteases are essential in many physiological processes, including ...

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