PAPER Thapa A, Woo ER, Chi EY, Sharoar MG, Jin HG, Shin SY, Park IS

Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures.

Biochemistry. 2011 Apr 5;50(13):2445-55. PubMed: 21322641

PAPER Kolykhalov IV, Rassadina GA, Gavrilova SI, Gerasimov NP

[Cholinergic therapy of Alzheimer's disease and its effect on health and quality of life of caregivers to the patients].

Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(5 Pt 1):33-8. PubMed: 21322823

PAPER Shah S, Federoff HJ

Therapeutic potential of vaccines for Alzheimer's disease.

Immunotherapy. 2011 Feb;3(2):287-98. PubMed: 21322764

PAPER Dekosky ST, Carrillo MC, Phelps C, Knopman D, Petersen RC, Frank R, Schenk D, Masterman D, Siemers ER, Cedarbaum JM, Gold M, Miller DS, Morimoto BH, Khachaturian AS, Mohs RC

Revision of the criteria for Alzheimer’s disease: A symposium.

Alzheimers Dement. 2011 Jan;7(1):e1-12. PubMed: 21322828

PAPER Garai K, Baban B, Frieden C

Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles.

Biochemistry. 2011 Apr 5;50(13):2550-8. PubMed: 21322570

Philipp Jaeger on Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

COMMENT This paper by Tamboli at al. is a very interesting study supporting the potential role of autophagy in APP turnover and degradation. The authors show a connection between sphingolipid accumulation and a disturbance in autophagic flux, which in turn impair

Timothy Clark on Endowed Lectureship to Honor the Late Mark Smith

COMMENT I only met Dr. Smith once, but I heard many things about him through George Perry. I had hoped to one day do an internship at Case under Dr. Smith. I hope many other students will be able to benefit from Mark Smith's legacy. gva334 0

Zhihui Sun

Upenn
Philadelphia, Canada

Glyn Wainwright on Is Alzheimer's a Type 3 Diabetes?

COMMENT My associates and I were originally exploring cholesterol depletion, and we kept running into the same compelling idea about oxidative stress in neurons. We published a review, which is referenced below. glynthincs 0 Nutrition and Alzheimer's disease

Glyn Wainwright on Cholesterol and Alzheimer's—Charging Fast But Still at a Distance from Solid Answers

COMMENT My associates were looking at cholesterol depletions and clinical effects of cholesterol loss from plasma membranes, and realized that the neuronal impact was huge. In a second review paper referenced below, we explored the implications of cholesterol dep

Michael Schlossmacher on Herpes Simplex and Alzheimer’s—Time to Think Again?

COMMENT I have been intrigued by these ideas since Itzhaki and others presented some of the data in Salzburg at the AD/PD meeting in 2007. Here are some issues that come to mind: Most cases of AD are sporadic, representing a complex disease with genetic and envir

PAPER Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4710-5. PubMed: 11296300

Sam Scrivani

Chelmsford, United States

Takaomi Saido on Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts.

COMMENT A very important and suggestive study. 0 saido

Takaomi Saido on Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.

COMMENT A very indicative study. 0 saido