PAPER Wille H, Drewes G, Biernat J, Mandelkow EM, Mandelkow E
PAPER Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.EMBO J. 1992 Apr;11(4):1593-7. PubMed: 1563356
London, United Kingdom
Taiwan, Province of China
RESEARCH NEWS 2016-05-25 Research News Researchers believe Aβ oligomers do much of their dirty work at the synapse. If so, could protecting synaptic receptors from Aβ preserve cognition? In the May 31 Cell Reports, researchers led by Stephen Ferguson at the University of Ottawa ...
PAPER Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. Epub 2015 Feb 9 PubMed: 25665805
UCSFSan Francisco, United States
PAPER de Leon MJ, McRae T, Tsai JR, George AE, Marcus DL, Freedman M, Wolf AP, McEwen B2899791
CONFERENCE 2016-09-14 00:00:00-2016-09-17 00:00:00 Kiel, Germany 14 – 17 September 2016 Proteases constitute 1–5 percent of eukaryotic genes and the human genome encodes 588 predicted proteolytic enzymes. The functions of proteases are essential in many physiological processes, including ...
COMMENT I was very impressed with this sleep-mTORC1 study from Ted Abel’s lab. To my knowledge this is the first time that anyone found a specific molecular pathway, and even better, a specific molecular manipulation, that addresses the epidemic of sleep ...
COMMENT I think this research is significant for a couple of reasons. As with our previous work, this study actually measures the levels of persistent toxicants in the body so that specific chemicals that may contribute are identified. This is particularly ...
COMMENT This is a small, short-term but exciting study investigating the possible effects of Liraglutide on disease progression in Alzheimer’s. The headline findings are that patients on the active drug had a cessation in the decline of glucose metabolism in the ...
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