PAPER Evans-Roberts CE, Turnbull OH
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331254 RESULTS
PAPER Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A
Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.
Neuroscience. 2011 Mar 17;177:298-307. PubMed: 21238544PAPER Greenough MA, Volitakis I, Li QX, Laughton K, Evin G, Ho M, Dalziel AH, Camakaris J, Bush AI
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
J Biol Chem. 2011 Mar 18;286(11):9776-86. PubMed: 21239495PAPER Wang LZ, Yu JT, Miao D, Wu ZC, Zong Y, Wen CQ, Tan L
Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population.
Brain Res. 2011 Mar 24;1381:202-7. PubMed: 21236243PAPER Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R
Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential.
Curr Aging Sci. 2011 Jul;4(2):118-27. PubMed: 21235496PAPER Aerts MB, Esselink RA, Abdo WF, Bloem BR, Verbeek MM
CSF α-synuclein does not differentiate between parkinsonian disorders.
Neurobiol Aging. 2012 Feb;33(2):430.e1-3. PubMed: 21236518PAPER Bettermann K, Arnold AM, Williamson J, Rapp S, Sink K, Toole JF, Carlson MC, Yasar S, Dekosky S, Burke GL
Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study.
J Stroke Cerebrovasc Dis. 2012 Aug 1;21(6):436-44. PubMed: 21236699PAPER Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
Behav Brain Res. 2011 Jul 7;220(2):338-43. PubMed: 21238494PAPER Mancuso C, Siciliano R, Barone E
Curcumin and Alzheimer disease: this marriage is not to be performed.
J Biol Chem. 2011 Jan 21;286(3):le3; author reply le4. PubMed: 21239508PAPER Zhang C, Tanzi RE
Response to mancuso et Al.: curcumin and Alzheimer disease: this marriage is not to be performed.
J Biol Chem. 2011 Jan 21;286(3):le4. PubMed: 21239509Ruiqing Ni
ETH Zurich & University of ZurichZurich, Switzerland
Cyrus Bett
La Jolla, United States
Roberto Malinow on Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
COMMENT I am intrigued by the findings regarding changes in transmission in the dentate gyrus of APP Tg animals. The authors find an increase in miniature inhibitory post-synaptic (IPSC) current frequency, but a decrease in "spontaneous" IPSC frequency
Lars M. Ittner on Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.
COMMENT This is nice work by Hoover and colleagues providing yet another piece of important evidence for the role(s) of tau in the post-synapse. While we showed before that endogenous mouse tau is associated with the post-synaptic density (PSD) (Ittner et al., 20
Jurgen Claassen on Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease.
COMMENT This paper provides in vivo evidence for microvascular changes in AD. 0 j.claassen
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