PAPER Malpass K

Alzheimer disease: a novel biomarker to detect early-stage Alzheimer disease.

Nat Rev Neurol. 2011 Aug;7(8):420. PubMed: 21769122

PAPER Galvin JE, Meuser TM, Boise L, Connell CM

Internet-Based Dementia Resources: Physician Attitudes and Practices.

J Appl Gerontol. 2011 Aug;30(4):513-523. PubMed: 21769164

PAPER Shaerzadeh F, Alamdary SZ, Esmaeili MA, Sarvestani NN, Khodagholi F

Neuroprotective effect of Salvia sahendica is mediated by restoration of mitochondrial function and inhibition of endoplasmic reticulum stress.

Neurochem Res. 2011 Dec;36(12):2216-26. PubMed: 21769643

Abubakar Yaro

Maria Corrada

University of California, Irvine
Irvine, United States

Lars Nilsson on Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.

COMMENT The important early observation that PDAPP mice hemizygous for murine ApoE (PDAPP x mouse ApoE+/-) had less Aβ and amyloid burden than those with two copies (PDAPP x mouse ApoE+/+) (Bales et al., 1997; Bales et al., 1999) is unfortunately seldom mentioned

Michael Heneka on Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons.

COMMENT This is a highly interesting paper that sheds further light on the fate of the noradrenergic system during the course of Alzheimer's disease. Central noradrenergic neurons, located in the locus ceruleus (LC), degenerate early in AD, and subsequently,

Stephen Strittmatter

Yale University School of Medicine
United States

Wai-Tong Chien on Parkinson’s: Thinking Outside the Brain’s Black Box

COMMENT This is a useful and important paper on the experimental findings to support Braak's hypothesis, which has provided new ideas for researchers to test the role of functional tracts and brain structure in Alzheimer's disease, including Lewy bodies

PAPER Takeda A, Baba T, Kikuchi A, Sugeno N, Hasegawa T, Itoyama Y, Ishioka T, Hirayama K, Mori E

[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].

Rinsho Shinkeigaku. 2009 Nov;49(11):888-9. PubMed: 20030239

Haakon Nygaard

Yale University School of Medicine
United States

Lane Simonian on Proinflammatory cytokines, sickness behavior, and Alzheimer disease.

COMMENT As Holmes and his colleagues have discovered, tumor necrosis factor-α plays a key role in Alzheimer's disease—although that role may be more due to its induction of peroxynitrites than to inflammation (Hikiji et al., 2000). Peroxynitrite damage is wi

PAPER Hikiji H, Shin WS, Koizumi T, Takato T, Susami T, Koizumi Y, Okai-Matsuo Y, Toyo-Oka T

Peroxynitrite production by TNF-alpha and IL-1beta: implication for suppression of osteoblastic differentiation.

Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1031-7. PubMed: 10827005

Chris Carter on 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.

COMMENT This is more a question than a comment. Both PIB and β amyloid antibodies bind to the same relatively small peptide, β amyloid. Is there any work testing whether they displace each other? 0 chris_car

Ivan Martynikhin

St.Petersburg Pavlov State Medical University
St. Petersburg, Russian Federation