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Aduhelm

THERAPEUTICS Biogen Neurimmune Aducanumab BIIB037 Immunotherapy (passive) Amyloid-Related A Phase 1 safety and pharmacokinetics study began with a single-ascending-dose trial of 0.3 mg/kg to 30 mg/kg intravenous BIIB037 in 56 people with mild to moderate AD. Participa

Glutamate Receptor Links Aβ-Prion Complex with Fyn, Synaptic Damage

RESEARCH NEWS 2013-09-11 Research News Some research suggests that amyloid β oligomers bind cellular prion protein (PrPc) at the cell surface, but how could that wreak havoc within the cell? In the September 4 Neuron, researchers led by Stephen Strittmatter of Yale University Sch

PAPER van Blitterswijk M, DeJesus-Hernandez M, Niemantsverdriet E, Murray ME, Heckman MG, Diehl NN, Brown PH, Baker MC, Finch NA, Bauer PO, Serrano G, Beach TG, Josephs KA, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Boylan KB, Petrucelli L, Dickson DW, Rademakers R

Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study.

Lancet Neurol. 2013 Oct;12(10):978-88. Epub 2013 Sep 5 PubMed: 24011653

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