CD11b/CD18 αMβ2 Integrin (ED7)

ANTIBODY monoclonal ED7 manufacturer Cat# MAB1408 immunogn = spleen cell homogenate with FCA liquid, ascites, protein-A affinity purified, PBS, azide. recognizes a membrane antigen on rat macrophages, monocytes, dendritic cells and granulocytes; recognizes small r

Wai-Tong Chien on Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study.

COMMENT I am very delighted to further understand that exercise can help preserve gray matter and thus may help prevent Alzheimer's disease in older people. This is particularly critical to populations at greatest lifetime risk for development of AD. Everywh

PAPER Radford SE, Gosal WS, Platt GW

Towards an understanding of the structural molecular mechanism of beta(2)-microglobulin amyloid formation in vitro.

Biochim Biophys Acta. 2005 Nov 10;1753(1):51-63. PubMed: 16099226

PAPER Liu C, Sawaya MR, Eisenberg D

β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages.

Nat Struct Mol Biol. 2011 Jan;18(1):49-55. PubMed: 21131979

PAPER Giorgetti S, Rossi A, Mangione P, Raimondi S, Marini S, Stoppini M, Corazza A, Viglino P, Esposito G, Cetta G, Merlini G, Bellotti V

Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.

Protein Sci. 2005 Mar;14(3):696-702. PubMed: 15689502

PAPER Esposito G, Michelutti R, Verdone G, Viglino P, Hernández H, Robinson CV, Amoresano A, Dal Piaz F, Monti M, Pucci P, Mangione P, Stoppini M, Merlini G, Ferri G, Bellotti V

Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.

Protein Sci. 2000 May;9(5):831-45. PubMed: 10850793

PAPER Bellotti V, Stoppini M, Mangione P, Sunde M, Robinson C, Asti L, Brancaccio D, Ferri G

Beta2-microglobulin can be refolded into a native state from ex vivo amyloid fibrils.

Eur J Biochem. 1998 Nov 15;258(1):61-7. PubMed: 9851692

Beril Mert

Turkey

CD11b αM Integrin (OX-42)

ANTIBODY monoclonal OX-42 manufacturer Cat# CBL1512 immunogn = rat peritoneal macrophages liquid, protein-A affinity purified, PBS, azide.<br />Also available protein-G purified, PBS, no preservatives, CBL1512Z, or FITC conjugated, CBL1512F recognizes most m

Brian O’Nuallain

University College Dublin
Dublin, Ireland

Mathias Jucker on Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

COMMENT Reply to comments by Christopher Carter, Nunzio Pomara, and Gabrielle Lake We thank Drs. Carter, Pomara, and Lake for their thoughtful comments on our work. Christopher Carter asks whether our observations may be related to antibodies to β amyloid generat

CD11b αM Integrin (44)

ANTIBODY monoclonal 44 manufacturer Cat# CBL145 immunogn = synovial cells and human monocytes liquid, purified, PBS, BSA, azide.<br />Also available Phycoerythrin conjugated, CBL145P reacts with the integrin heterodimer of 165 kDa which comprises the CD11b r

PAPER Jucker M

The benefits and limitations of animal models for translational research in neurodegenerative diseases.

Nat Med. 2010 Nov;16(11):1210-4. PubMed: 21052075

Matthias Staufenbiel

Germany

Miami: Updates on J-ADNI, 18F Tracers, Biopsies

CONFERENCE COVERAGE 2011-02-03 Conference Coverage Kenji Ishii of the Tokyo Metropolitan Institute of Gerontology updated the audience at the 5th annual Human Amyloid Imaging conference, held in Miami, Florida, on 14-15 January 2011, about where the Japanese ADNI stands at this point.