PAPER Jang YH, Min do

Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways.

J Biol Chem. 2011 Feb 11;286(6):4680-9. PubMed: 21113078

PAPER Kutzing MK, Langhammer CG, Luo V, Lakdawala H, Firestein BL

Automated Sholl analysis of digitized neuronal morphology at multiple scales.

J Vis Exp. 2010;(45) PubMed: 21113115

PAPER Li X, Coyle D, Maguire L, Watson DR, McGinnity TM

Gray matter concentration and effective connectivity changes in Alzheimer's disease: a longitudinal structural MRI study.

Neuroradiology. 2011 Oct;53(10):733-48. PubMed: 21113707

PAPER Camozzato AL, Kochhann R, Godinho C, Costa A, Chaves ML

Validation of a telephone screening test for Alzheimer's disease.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2011 Mar;18(2):180-94. PubMed: 21113824

PAPER Stravalaci M, Beeg M, Salmona M, Gobbi M

Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ(1-42) peptide, synthesized by depsi-peptide technique.

Biosens Bioelectron. 2011 Jan 15;26(5):2772-5. PubMed: 21112205

PAPER Weiss R, Lifshitz V, Frenkel D

TGF-β1 affects endothelial cell interaction with macrophages and T cells leading to the development of cerebrovascular amyloidosis.

Brain Behav Immun. 2011 Jul;25(5):1017-24. PubMed: 21112386

PAPER Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.

Nature. 2011 Jan 6;469(7328):47-52. PubMed: 21113149

PAPER Kapai NA, Solntseva EI, Skrebitskii VG

Donepezil eliminates suppressive effects of β-amyloid peptide (1-42) on long-term potentiation in the hippocampus.

Bull Exp Biol Med. 2010 Jul;149(1):33-6. PubMed: 21113452

PAPER Ott S, Henkel AW, Henkel MK, Redzic ZB, Kornhuber J, Wiltfang J

Pre-aggregated Aβ1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application.

Mol Cell Biochem. 2011 Mar;349(1-2):169-77. PubMed: 21113648

Elizabeth Heilig on Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

COMMENT In this study, Gong et al. have conducted a careful, systematic analysis of the role of PS1 luminal loop 1 (LL1) and the adjacent transmembrane region, TM2, in γ-secretase complex formation, presenilinase cleavage, and substrate cleavage activity using a

Yuli Wang

Gerontologist, Instructor certified for Dementia Care Practitioner)
Chatsworth, United States

Jenny McNeely

Tallahassee, United States

Brad Bobrin

The Reading Hospital and Medical Center
West Reading, United States

Hans-Ulrich Demuth on Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.

COMMENT The Therapeutic and Diagnostic Potential of Anti AβpE3 Strategies The article by the team led by Wirths and Bayer is a further step forward in clarifying the role of an abundant and apparently very toxic Aβ species in human brain deposits: N-pyroglutamyl

Sarah Westwood