RESEARCH MODELS This model was the first reported APP transgenic mouse. It overexpressed the human APP 751 isoform which includes the Kunitz serine protease inhibitor domain. The transgene was expressed throughout the brain from a rat neural-specific enolase (NSE) ...
PAPER Higgins LS, Rodems JM, Catalano R, Quon D, Cordell B
Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.Proc Natl Acad Sci U S A. 1995 May 9;92(10):4402-6. PubMed: 7753818
PAPER Snyder GL, Vanover KE, Zhu H, Miller DB, O'Callaghan JP, Tomesch J, Li P, Zhang Q, Krishnan V, Hendrick JP, Nestler EJ, Davis RE, Wennogle LP, Mates S25120104
PAPER Davis RE, Vanover KE, Zhou Y, Brašić JR, Guevara M, Bisuna B, Ye W, Raymont V, Willis W, Kumar A, Gapasin L, Goldwater DR, Mates S, Wong DF
ITI-007 demonstrates brain occupancy at serotonin 5-HT₂A and dopamine D₂ receptors and serotonin transporters using positron emission tomography in healthy volunteers.Psychopharmacology (Berl). 2015 Aug;232(15):2863-72. Epub 2015 Apr 7 PubMed: 25843749
THERAPEUTICS Add Private note Add An editorial note Bristol-Myers Squibb Intra-Cellular Therapies, Inc. Small Molecule Other Neurotransmitters In 2014, Intra-Cellular Therapies ran a Phase 1/2 dose-escalation study of up to 30 mg/d in 30 old healthy volunteers and ...
Ron Louie on Lilliputian Effect Size Fells Phase 3 Trial of Solanezumab, Leaving Its Future Uncertain
COMMENT We are grateful that Lilly tried so hard, and will be interested in their conclusions about the utility of amyloid imaging and biomarkers. With the 2025 "deadline" looming, next steps might include a more aggressive empiric repurposing approach, ...
William Rosenblum on Lilliputian Effect Size Fells Phase 3 Trial of Solanezumab, Leaving Its Future Uncertain
COMMENT Unfortunately in the absence of means to image soluble Aβ in brain, there is no way to know whether the treatment actually diminished this target. In fact, antibodies directed against soluble Aβ might cause enhanced release of soluble Aβ from insoluble ...
Angel Golimstok on Lilliputian Effect Size Fells Phase 3 Trial of Solanezumab, Leaving Its Future Uncertain
COMMENT All anti-Aβ antibodies failed to slow cognitive decline in people with mild Alzheimer’s disease. It's time to begin another line of research. In the future we´ll have to try combined treatment and only in young patients with early Alzheimer's. ...
COMMENT How chronic traumatic brain injury leads to dementia and increases the risk for neurodegenerative disease is not known. This study by Coughlin et al. provides evidence for the role of chronic inflammation, perhaps already early in these processes, by ...
RESEARCH NEWS 2016-12-02 Add Private note Add An editorial note Research News Research has shown that sports-related head injuries lead to future amyloid and tau pathology, as well as a higher risk of dementia and neuropsychiatric symptoms. However, the link between traumatic ...
PAPER Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.Biol Psychiatry. 2014 Oct 1;76(7):575-84. Epub 2013 Oct 25 PubMed: 24289885
PAPER Witcher KG, Godbout JP
Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?JAMA Neurol. 2016 Nov 28; PubMed: 27893875
PAPER Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X, Peters ME, Dougherty JW, Vranesic M, Koo SM, Ahn HH, Lee M, Cottrell C, Sair HI, Sawa A, Munro CA, Nowinski CJ, Dannals RF, Lyketsos CG, Kassiou M, Smith G, Caffo B, Mori S, Guilarte TR, Pomper MG
Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players.JAMA Neurol. 2016 Nov 28; PubMed: 27893897
PAPER Rowe RK, Ellis GI, Harrison JL, Bachstetter AD, Corder GF, Van Eldik LJ, Taylor BK, Marti F, Lifshitz J
Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.Mol Pain. 2016;12 Print 2016 PubMed: 27178244
PAPER Coughlin JM, Wang Y, Munro CA, Ma S, Yue C, Chen S, Airan R, Kim PK, Adams AV, Garcia C, Higgs C, Sair HI, Sawa A, Smith G, Lyketsos CG, Caffo B, Kassiou M, Guilarte TR, Pomper MG
Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study.Neurobiol Dis. 2015 Feb;74:58-65. Epub 2014 Nov 7 PubMed: 25447235
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