172239 RESULTS

Live-Cell Studies Blame Arginine Peptides for C9ORF72’s Crimes

RESEARCH NEWS 2014-12-19 Research News A variety of abnormal RNAs and peptides result from repeats in the C9ORF72 gene, the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Which of these funky molecules instigates the death of cortical and ...

Iryna Benilova on Meet Sigma2, a New Aβ Receptor?

COMMENT Neurons contain multiple Aβ binding sites, from membrane receptors to gangliosides. It is currently unclear whether Aβ toxicity is mediated by ligand-receptor interactions or a less-specific mechanism. Using a phenotypic assay for membrane trafficking, ...

Meet Sigma2, a New Aβ Receptor?

CONFERENCE COVERAGE 2014-12-19 Conference Coverage Prion protein, insulin receptors, immunoglobulin-like receptors, PirB, unspecified membrane phospholipids, the list goes on … Now, add another purported Aβ receptor. At the Society for Neuroscience annual meeting in Washington, D.C., ...

Just For Her? Study of Women’s Biology Offers New Therapeutic Angle

CONFERENCE COVERAGE 2014-12-19 Conference Coverage It’s not news that women run a higher risk of Alzheimer’s disease than men. Nor is the thought that this has something to do with female sex hormones ebbing after menopause. Alas, hormone replacement has not worked, and it’s time for ...

Try This at Home: Cognitive Testing in the Age of Prevention Trials?

CONFERENCE COVERAGE 2014-12-19 Conference Coverage As Alzheimer’s treatment pushes into ever-earlier disease stages, researchers need better ways of finding people who are at risk for cognitive decline. They also need better ways of cheaply tracking cognition in those people over multi ...

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