330883 RESULTS
RESEARCH MODELS Modification Details Transgene expressing wild-type human BACE1 driven by the mouse Thy1 promoter. Neuropathology Not observed. Cognition/Behavior Unknown. Other Phenotypes Transgene is expressed in neurons only. No change in the processing of endogenous
RESEARCH MODELS Neuropathology Increased Aβ42 in the cortex and hippocampus of 12 month-old mice, but no plaques. Increased tau phosphorylation and TUNEL-stained nuclei relative to control mice (Hwang et al., 2004). Cognition/Behavior In water maze tests, 12 month-old mi
United States
COMMUNITY NEWS 2013-11-15 Community News Clinical trial data typically have been shrouded in secrecy, but major new initiatives are pulling back the veil and promising to provide greater access. The European Medicines Agency (EMA) plans to publish summary trial data from all new a
CONFERENCE COVERAGE 2013-11-15 Conference Coverage Researchers interested in amyotrophic lateral sclerosis and other disorders of RNA arrived early for the Society for Neuroscience annual meeting this year, attending “RNA Metabolism in Neurological Disease,” a two-day satellite symposi
PAPER Alvarez YD, Fauerbach JA, Pellegrotti JV, Jovin TM, Jares-Erijman EA, Stefani FD
PAPER Wang L, Zhai YQ, Xu LL, Qiao C, Sun XL, Ding JH, Lu M, Hu G
PAPER Fujita K, Matsui N, Takahashi Y, Iwasaki Y, Yoshida M, Yuasa T, Izumi Y, Kaji R
PAPER Conraux L, Pech C, Guerraoui H, Loyaux D, Ferrara P, Guillemot JC, Meininger V, Pradat PF, Salachas F, Bruneteau G, Le Forestier N, Lacomblez L
PAPER Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH
PAPER Beed P, Gundlfinger A, Schneiderbauer S, Song J, Böhm C, Burgalossi A, Brecht M, Vida I, Schmitz D
PAPER Gao L, She H, Li W, Zeng J, Zhu J, Jones DP, Mao Z, Gao G, Yang Q
PAPER Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV
PAPER Abada YS, Nguyen HP, Ellenbroek B, Schreiber R
PAPER Du X, Ewert DL, Cheng W, West MB, Lu J, Li W, Floyd RA, Kopke RD
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