PAPER Sitek EJ, Narożańska E, Pepłońska B, Filipek S, Barczak A, Styczyńska M, Mlynarczyk K, Brockhuis B, Portelius E, Religa D, Barcikowska M, Sławek J, Żekanowski C

A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene.

PLoS One. 2013;8(4):e61074. PubMed: 23593396

PAPER Wang M, Turko IV

Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex.

PLoS One. 2013;8(4):e61498. PubMed: 23593485

PAPER Doi Y, Takeuchi H, Horiuchi H, Hanyu T, Kawanokuchi J, Jin S, Parajuli B, Sonobe Y, Mizuno T, Suzumura A

Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons.

PLoS One. 2013;8(4):e61988. PubMed: 23593505

PAPER Morbelli S, Perneczky R, Drzezga A, Frisoni GB, Caroli A, van Berckel BN, Ossenkoppele R, Guedj E, Didic M, Brugnolo A, Naseri M, Sambuceti G, Pagani M, Nobili F

Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project.

J Nucl Med. 2013 Jun;54(6):894-902. PubMed: 23591639

Jill Chabala

Pfizer
United States

Volha Tryputsen

United States

Safe at 4 Grams? No ARIA at High Dose of Human Aβ Antibody

CONFERENCE COVERAGE 2013-04-18 Conference Coverage Read a PDF of the entire series. This is Part 2 of a two-part series on AD/PD 2013 immunotherapy news. See also Part 1. At the 11th International Conference on Alzheimer’s and Parkinson’s Diseases, held 6-10 March in Florence, Italy, T

PAPER Trojsi F, Corbo D, Caiazzo G, Piccirillo G, Monsurrò MR, Cirillo S, Esposito F, Tedeschi G

Motor and extramotor neurodegeneration in amyotrophic lateral sclerosis: A 3T high angular resolution diffusion imaging (HARDI) study.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr 16; PubMed: 23586325

PAPER Burrell JR, Carpenter RH, Hodges JR, Kiernan MC

Early saccades in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):294-301. PubMed: 23586894

PAPER George S, Rey NL, Reichenbach N, Steiner JA, Brundin P

α-Synuclein: the long distance runner.

Brain Pathol. 2013 May;23(3):350-7. PubMed: 23587141

PAPER González H, Contreras F, Prado C, Elgueta D, Franz D, Bernales S, Pacheco R

Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease.

J Immunol. 2013 May 15;190(10):5048-56. PubMed: 23589621

PAPER Dombroski BA, Galasko DR, Mata IF, Zabetian CP, Craig UK, Garruto RM, Oyanagi K, Schellenberg GD

C9orf72 hexanucleotide repeat expansion and guam amyotrophic lateral sclerosis-parkinsonism-dementia complex.

JAMA Neurol. 2013 Jun 1;70(6):742-5. PubMed: 23588498

PAPER Kretzschmar H, Tatzelt J

Prion disease: a tale of folds and strains.

Brain Pathol. 2013 May;23(3):321-32. PubMed: 23587138

PAPER Apolloni S, Parisi C, Pesaresi MG, Rossi S, Carrì MT, Cozzolino M, Volonté C, D'Ambrosi N

The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis.

J Immunol. 2013 May 15;190(10):5187-95. PubMed: 23589615

PAPER Deng PY, Rotman Z, Blundon JA, Cho Y, Cui J, Cavalli V, Zakharenko SS, Klyachko VA

FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels.

Neuron. 2013 Feb 20;77(4):696-711. PubMed: 23439122